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Pharmacokinetics & Pharmacodynamics: Drug Absorption, Distribution, Metabolism, Excretion, Exams of Pharmacokinetics

A.T. Still University of Health Sciences (ATSU)Pharmacokinetics

An overview of pharmacokinetics and pharmacodynamics, focusing on the four parts of pharmacokinetics - absorption, distribution, metabolism, and excretion. Learn about the definitions of pharmacokinetics and pharmacodynamics, the pharmaceutical phase, passive and active transport, absorption factors, common routes of administration, and more.

Typology: Exams

2023/2024

Available from 03/26/2024

DrShirleyAurora
DrShirleyAurora 🇺🇸

4.4

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Pharmacokinetics and dynamics
Pharmacokinetic Phase (four parts) -
ADME
A: absorbed
D: distribution
M: metabolized
E: excreted from the body
Define: Pharmacokinetic -
What the body does to the drug, or how the drug moves through the body.
Define: Pharmacodynamics -
How the drug affects the body. The chemical and physiologic changes that occur due to the
action of the drug.
Pharmaceutical phase -
The study of the different forms of a single drug affects the action and rate of absorption.
Passive transport (from what concentration to what concentration) -
Higher -> Lower
No energy needed
down the concentration gradient
Active transport (from what concentration to what concentration) -
Lower -> Higher
Up the concentration gradient
Needs energy to facilitate transport
pf3

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Pharmacokinetics and dynamics

Pharmacokinetic Phase (four parts) - ADME A: absorbed D: distribution M: metabolized E: excreted from the body Define: Pharmacokinetic - What the body does to the drug, or how the drug moves through the body. Define: Pharmacodynamics - How the drug affects the body. The chemical and physiologic changes that occur due to the action of the drug. Pharmaceutical phase - The study of the different forms of a single drug affects the action and rate of absorption. Passive transport (from what concentration to what concentration) - Higher -> Lower No energy needed down the concentration gradient Active transport (from what concentration to what concentration) - Lower -> Higher Up the concentration gradient Needs energy to facilitate transport

Absorption - the movement of a drug from the origin to the blood stream or tissues. Such as from the small intestine into the blood stream. Factor that effect absorbtion -

  • pH of body fluids
  • Heat on the drug in storage
  • light
  • air or humidity drugs need to be sealed in their container in an temp and light controlled environment. most common route of administration - Oral 80% (buccal, sublingual,) What can cross the Blood Brain Barrier - Lipid soluble drugs Liver metabolism phases - Phase I: oxidation (add o2 to drug) Phase II:Conjugation
  • adds molecule or makes it more polar to be able to be excreted by the kidneys. First pass effect - Often 90% of a drug is metabolized by the liver the first time through the portal vein. Induction - chronic exposure to a drug can lead to the body to make more enzymes for it so it does not last as long as a person not chronically on the drug.