O2
O2
O2
O2
O2 O2
O2 O2
METABOLISM OF
PYRUVATE
Its time to get aerobic
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Pyruvate - Biochemistry - Lecture Slides, Slides of Biochemistry
Pyruvate, Pyruvate Structure, Oxidation of Carbon, Reactions of Pyruvate, Pyruvate Decarboxylase, Pyruvate Dehydrogenase, Pyruvate Carboxylase, Lactate Dehydrogenase, Decarboxylation Reactions, The Energy Story of Glycolysis are main points of this lecture.
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2011/2012
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O 2 O 2
O 2
O 2
O 2 O 2
O 2 O 2
METABOLISM OF
PYRUVATE
Its time to get aerobic
COO
C=O
CH 3
a ketoacid
Carboxyl group (acid)
Ketone group (carbonyl)
Methyl group
Pyruvate Structure
CH 3 C-OH C=O C=O
O
C
O
O
Net = – 2
Oxidation of Carbon
Look for one NAD+^ for each glyceraldehyde-3-PO 4 oxidized to pyruvate
- OH
H-C-OH
CHO
CH 2 OHP
Glyceraldehyde
3-Phosphate
O : (^) C O
C O
O
O
C
O
Decarboxylation Reactions
Two Types: non-oxidative and oxidative
No change in oxidation state of carbonyl C
H 3 C-C:COO-
O
H 3 C-C+
O
NAD+ NADH
H 3 C-C:
O
CO 2
CO 2
Oxidized carbonyl C Oxidative
Non-oxidative H 3 C-C:H O
H+
H 3 C-C-OH
O
H 2 O
The Energy Story of Glycolysis
Overall ANAEROBIC (no O 2 )
Glucose + 2ADP + 2Pi 2 Lactate + 2ATP + 2H 2 O
Glucose + 2ADP + 2Pi 2 Ethanol + 2CO 2 +2ATP + 2H 2 O
Overall AEROBIC
Yeast
Glucose + 2ADP + 2Pi + 2NAD+ 2 Pyruvate + 2ATP + 2NADH + 2H+^ + 2H 2 O
6 ATPs
Glycolysis
Oxidative phosphorylation
pyruvate
Krebs Cycle
3 NADH
Glucose
Galactose Fructose Mannose
Fatty Acids
1 FADH 2
Lactate
Amino Acids
O 2
H 2
Anaerobic
Aerobic
Acetyl-Coenzyme A
Pyruvate dehydrogenase Complex
Pyruvate dehydrogenase Dihydrolipoyl transacetylase Dihydrolipoyl dehydrogenase
NAD
Coenzyme A
Lipoic acid
Thiamin pyrophosphate
FAD
N
CH 3 N NH 2
CH 2
P O P
O O O
O
O
O
Thiamin pyrophosphate
CH 3 C COO
O (^) Pyruvate
..
N S
CH 3 CH^2 CH^2
Carbanion
Vitamin B-
: + CO 2
Dihydrolipoate
CH 2 CH CH 2 CH 2 CH 2 CH 2
CH 2
HS SH
COO
6,8 Dithiooctonoate
(Reduced, gained 2 electrons)
S S
CH 2
CH 2
CH CH 2 CH 2 CH 2 CH 2 COO
(Oxidized, lost 2 electrons)
Long hydrocarbon chain
Disulfide bond
E 3
Pyruvate Dehydrogenase Complex
FAD
TPP E 1 E 2
Pyruvate Dehydrogenase
Dihydrolipoyl Transacetylase
Dihydrolipoyl dehydrogenase
..
CH 3 -C
OH
C-CH 3
O
..
H 2
..
Acetyl-CoA
HS-CoA
NAD+
NADH ..
..
CH 3 -C
O
Textbook p471-
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