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Download Immunology Terms: Antigens, Immunogens, Epitopes, Antibodies, and Fc Receptors and more Quizzes Immunology in PDF only on Docsity!
Antigen
molecules that can be bound by antibodies or T cell
receptors
TERM 2
Immunogen
DEFINITION 2
antigens that can stimulate an immune responses
TERM 3
Antigens, Immunogens
DEFINITION 3
All immunogens are ___, but not all antigens are ___.
TERM 4
Haptens
DEFINITION 4
small molecules that are antigenic but not immunogenic
TERM 5
Epitopes
DEFINITION 5
Antigenic Determinants of an antigen
immunological active regions on immunogens
specific for lymphocyte antigen receptors and antibodies
Multivalent antigens
antigens having 2 or more epitopes
TERM 7
Multivalent antibody
DEFINITION 7
Antibody having having 2 or more antigen binding sites
TERM 8
Hypervariable regions aka complementarity
determining region
DEFINITION 8
Found in both heavy and light chain V regions
HV1(CDR1), HV2 (CDR2), HV3 (CDR3).
high degree of amino acid variability in these regions
major binding sites for all the various antigens
TERM 9
Framework regions
DEFINITION 9
Intervening peptide sequences
TERM 10
Heavy chain
DEFINITION 10
The ____ determines an antibody's class or subclass.
antibody mediated effector function
neutralization, opsonization, complement activation (IgM and
IgG), antibody dependent dell-mediated cytotoxicity by NK
cells and other killer cells, and sensitizing mast cells.
TERM 17
Neutralization
DEFINITION 17
block antigen infection
TERM 18
opsonization
DEFINITION 18
promotion of phagocytosis of antigen by macrophages and
neutrophils
TERM 19
Fc receptors
DEFINITION 19
An _____ is a protein found on the surface of certain cells -
including B lymphocytes, follicular dendritic cells, natural
killer cells, macrophages, neutrophils, and mast cells - that
contribute to the protective functions of the immune system.
TERM 20
FcyRIII
DEFINITION 20
_____ is the only Fc receptor that NK cell expresses
FcyRIII
NK cells target cells by ADCC through _____
TERM 22
monoclonal antibody humanization
DEFINITION 22
1. prevents anti-antibody immune response2. engages
human effector cells through Fc region
TERM 23
Primary RNA transcript
DEFINITION 23
_____ almost always contains C mu and C delta
TERM 24
RNA splicing
DEFINITION 24
alternative _____ determines which C segment goes in
TERM 25
One turn/two turn rule
DEFINITION 25
a segment flanked by an RSS with a 12 bp spacer (one-turn)
can only join to one flanked by a 23 bp spacer (two-turn)
