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SOP Template developed by The UC Center for Laboratory Safety
Standard Operating Procedure
Sodium borohydride
This SOP is not complete until it has been signed and dated by the PI and relevant lab
personnel.
Print a copy and insert into your
Laboratory Safety Manual and Chemical Hygiene Plan.
Refer to instructions for assistance.
Department: Chemistry & Biochemistry - Chemical Engineering
Date SOP was written: (^) December 14, 2012
Date SOP was approved by PI/lab supervisor: (^) January 18, 2013
Principal Investigator: (^) Prof. Susannah Scott
Internal Lab Safety Coordinator/Lab Manager: (^) Stephanie Goubert-Renaudin
Lab Phone: 805-893-
Office Phone: (^) 805-893-
Emergency Contact: EH&S 24 hour line: 805-893- (Name and Phone Number)
Location(s) covered by this SOP:^ ESB 3324 and 3328 (Building/Room Number)
Type of SOP: Process Hazardous Chemical Hazardous Class
Purpose
Sodium Borohydride is a water reactive chemical. In contact with water releases flammable gases which may ignite spontaneously. It is both air and moisture sensitive. Sodium borohydride, also known as sodium tetrahydridoborate, is an inorganic compound with the formula NaBH4.By mixing it with water or an alcohol, it is more efficient at reduction. NaBH 4 will reduce many organic carbonyls, depending on the precise conditions, but the reductant will eventually decompose spontaneously to give hydrogen gas and borates. Hence, a written Standard Operating Procedure (SOP) is required to handle this chemical in a safe manner.
Physical & Chemical Properties/Definition of Chemical Group
Sodium borohydride is an odorless white to gray-white microcrystalline powder which often forms lumps. It is soluble in water, with which it reacts vigorously.
SOP Template developed by The UC Center for Laboratory Safety
Molecular Formula NaBH^4 Molar Mass 37.83 g/mol
Appearance white crystals hygroscopic Density 1.0740 g/cm^3 Melting Point 400 °C Bioling Point 500 °C Solubility in Water soluble, reacts with water
Solubility soluble in liquid ammonia, amines, pyridine
Potential Hazards/Toxicity
Emergency Overview OSHA Hazards Water Reactive, Toxic by ingestion, Toxic by skin absorption, Corrosive GHS Label elements, including precautionary statements Pictogram
Signal word Danger Hazard statement(s) H260 In contact with water releases flammable gases which may ignite spontaneously. H301 + H311 Toxic if swallowed or in contact with skin. H314 Causes severe skin burns and eye damage. Precautionary statement(s) P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. P231 + P232 Handle under inert gas. Protect from moisture. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/physician.
Potential Health Effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Skin Toxic if absorbed through skin. Causes skin burns. Eyes Causes eye burns. Ingestion Toxic if swallowed. Causes burns.
Personal Protective Equipment (PPE)
Respiratory protection
SOP Template developed by The UC Center for Laboratory Safety
- Air and moisture sensitive.
- Keep in a dry place (such as a desiccator or a dry box or glove box).
Materials to avoid Oxidizing agents, chemically active metals, acids, water & water based compounds.
Spill and Accident Procedure
Suitable extinguishing media DO NOT EXTINGUISH WITH WATER. Sand, sodium chloride, sodium carbonate, or a type IV fire extinguisher (type for metal fires) may be used. Extinguishing media which shall not be used for safety reasons Water
Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary.
ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Do not flush with water. Keep in suitable, closed containers for disposal
Chemical Spill Dial 9-911 and EH&S (805-893-3194)
Spill – Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9- 911 from campus phones (and 805-893-3446 from a cell phone) and EH&S (893-3194) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S immediately.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor and EH&S immediately.
Medical Emergency Dial 9-
Life Threatening Emergency, After Hours, Weekends and Holidays – Dial 9- 911 (or
805-893-3446 from a cell phone) or go to the Emergency Room of Goleta Valley Cottage Hospital at 351 South Patterson Avenue, Goleta (Phone number: 805-967-3411) Note: All Serious injuries must be reported to EH&S within 8 hours.
SOP Template developed by The UC Center for Laboratory Safety
Non-Life Threatening Emergency – Go to the Student Health Building, Building 588 (phone
number: 893-5361, hours: M, T, R, F 8am-4.30pm, W 9am - 4.30pm, R 5pm to 7pm by appointment). After hours go to the Emergency Room of Goleta Valley Cottage Hospital at 351 South Patterson Avenue, Goleta (Phone number: 805-967-3411) Note: All serious injuries must be reported to EH&S within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the
affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse \ and then enter your extension. After hours go to the nearest emergency room: the Emergency Room of Goleta Valley Cottage Hospital at 351 South Patterson Avenue, Goleta (Phone number: 805-967-3411). Note: All needle stick/puncture exposures must be reported to EH&S within 8 hours.
Decontamination/Waste Disposal Procedure Wearing proper PPE, collect all of the hydride in a suitable and carefully and completely quenched the hydride with isopropanol. Dispose in the appropriate waste container.
Label Waste
- Affix an hazardous waste tag on all waste as soon as the first drop of waste is added to the container Store Waste
- Store hazardous waste in closed containers, in secondary containment and in a designated location Dispose of Waste
- Dispose of regularly generated chemical waste within 90 days
- Call EH&S for questions (893-3194)
- Empty Containers o Dispose as hazardous waste
Safety Data Sheet (SDS) Location
SDS can be accessed online http://ehs.ucsb.edu/units/labsfty/labrsc/chemistry/lschemmsdsacc.htm
Protocol/Procedure
In our laboratory, sodium borohydride is used as a reducing agent and is prepared as aqueous or alcoholic solution.
Sodium borohydride is stored in a sealed container, away from moisture and water.
When handling sodium borohydride, nitrile or neoprene gloves, safety goggles and a flame retardant lab coat have to be worn.
Sodium borohydride is preferably handled in a glove box or under inert atmosphere. It can also be handled on a cleared and dry space within the fume hood.
SOP Template developed by The UC Center for Laboratory Safety
Youhong Wang
Jinghong Zhou
Jason Fendi
