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Solution to Homework3: Calculation of Creatinine Clearance and Renal Function, Assignments of Health sciences

University of Florida (UF)Health sciences

The solutions to homework3 questions related to the calculation of creatinine clearance (crcl) and renal function. The formula for crcl, the value of filtration rate (gfr) based on crcl, the effective renal blood flow (erbf), and the total renal blood flow (trbf). It also includes the calculation of creatinine non-renal clearance and renal clearance.

Typology: Assignments

Pre 2010

Uploaded on 03/10/2009

koofers-user-7eo
koofers-user-7eo 🇺🇸

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Solution to Homework3
1. a. CrCL=(140-age)*weight/70=(140-30)*70/70=110 mL/min
b. ke=0.00293*CrCL+0.014=0.00293*110+0.014=0.3363 hr-1
c. CLT=ke*Vd=0.3363*16.5=5.55 L/hr
d. kenonren=0.014 hr-1 and CLnonren=kenonren*Vd=0.014*16.5=0.231 L/hr
e. CLren=CLT-CLnonren=5.55-0.231=5.319 L/hr
f. C=Dose/Vd*Exp(-Ke*t) 5=100/16.5*Exp(-0.3363*t) t=0.572hr
2. B or B and D
3. A, C and D
4. a. False
b. False
c. False
d. False
e. False

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Solution to Homework

a. CrCL=(140-age)weight/70=(140-30)70/70=110 mL/min b. ke=0.00293CrCL+0.014=0.00293110+0.014=0.3363 hr

c. CLT=keVd=0.336316.5=5.55 L/hr d. kenonren=0.014 hr

and CLnonren=kenonrenVd=0.01416.5=0.231 L/hr e. CLren=CLT-CLnonren=5.55-0.231=5.319 L/hr f. C=Dose/VdExp(-Ket) 5=100/16.5Exp(-0.3363t) t=0.572hr

  1. B or B and D
  2. A, C and D
  3. a. False b. False c. False d. False e. False