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Typology: Summaries
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● NIV : Provides ventilatory support without an artificial airway (ETT or tracheostomy).
● Includes:
○ NPPV (Noninvasive Positive Pressure Ventilation) – most common.
○ CPAP (Continuous Positive Airway Pressure) – maintains constant pressure.
Acute Care Goals
● Improve gas exchange (↑ PaO₂, ↓ PaCO₂)
● Avoid intubation
● Decrease mortality and hospital stay
● Reduce VAP incidence
● Relieve dyspnea and distress
● Improve synchrony and comfort
Long-Term Goals
● Relieve symptoms
● Enhance quality of life
● Avoid hospitalization
● Improve survival and mobility
A. Acute Care Indications
Disorder Role of NIV Notes
COPD Exacerbation ✅ First-line
↓ Intubation, ↓
mortality
Asthma ⚠️ Controversial
Limited evidence
Cardiogenic Pulmonary Edema ✅ CPAP 8–12 cmH₂O,
Improves oxygenation
Hypoxemic Respiratory Failure
⚠️ Not routine Fail if PaO /FiO₂ ₂<
after 1 hr
Pneumonia Limited benefit Only for COPD +
pneumonia
Immunosuppressed/Post-Op ✅ Useful ↓ Intubation,
mortality
B. Long-Term Care Indications
Disorder NIV Use Notes
Nocturnal Hypoventilation ✅ COPD, OHS, NMD,
Kyphoscoliosis
Restrictive Thoracic Disease (ALS,
Kyphoscoliosis)
✅ Start when nocturnal
hypoventilation appears
Stable COPD ⚠️ Limited
evidence
May improve gas exchange
Obesity Hypoventilation (OHS) ✅ Use NPPV if CPAP fails
Acute Respiratory Failure – Criteria
At least 2 of the following:
● Use of accessory muscles or paradoxical breathing
Nasal mask Chronic/Night use More comfortable
Helmet / Nasal pillows / Mouthpiece Less common May help long-term users
Avoid overtightening → prevent skin necrosis.
● Noninvasive Ventilators: Leak compensation, IPAP/EPAP modes.
● Critical Care Ventilators: Precise control but poor leak tolerance.
● Portable/Home Care Ventilators: Battery powered; for transport or long-term use.
Parameter Initial Setting Adjust to...
PEEP (EPAP) 0–4 cmH O₂ Improve oxygenation / asynchrony
IPAP 2–4 cmH O above₂
Titrate to VT ≈ 4–6 mL/kg
FiO₂ Adjust for SpO ₂ > 90% Avoid hyperoxia
Increase gradually as tolerated.
● Improved ABGs : ↓ PaCO₂, ↑ pH, ↑ PaO₂
● ↓ RR, ↓ accessory muscle use, ↑ Vt
● Clinical improvement within 1–2 hours
Failure: Worsening ABGs, distress, no improvement → Intubate immediately
Problem Intervention
PaCO₂
↑ IPAP (VT) or ↑
Rate
PaCO₂
↓ IPAP (VT) or ↓
Rate
↑ PaO₂ ↑ FiO₂ or ↑ EPAP
↓ PaO₂ ↓ FiO₂ or ↓ EPAP
● Leaks, synchrony, comfort
● ABG trends
● Vital signs, SpO₂
● Watch for deterioration → Intubate if needed
● Mask discomfort or necrosis
● Air leaks → asynchrony, poor ventilation
● Aerophagia, sinus pain
● Aspiration, hypotension, pneumothorax (rare)
● Assess for candidacy
● Proper interface fitting
C. Allow patient to hold mask before strapping it on
D. Increase FiO ₂to 100%
A. Continue NIV and reassess in 2 hours
B. Increase EPAP by 2 cmH O₂
C. Intubate and initiate invasive ventilation
D. Add heated humidification
A. Increase IPAP
B. Decrease EPAP
C. Increase EPAP
D. Decrease FiO₂
A. Aspiration
B. Skin necrosis
C. Aerophagia
D. Barotrauma
A. CPAP 5 cmH O, 40% O₂ ₂
B. CPAP 10 cmH O, 100% O₂ ₂
C. IPAP 12, EPAP 6 cmH O₂
D. SIMV 12/min, VT 450 mL
A. Increase IPAP
B. Decrease IPAP
C. Increase EPAP
D. Increase FiO₂
A. Large air leak
B. Asynchrony
C. Patient cooperation
D. High PaO₂