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The notes cover information on polymers, carbohydrates, lipids, proteins, and nucleic acid, the four foundational biomolecules.
Typology: Study notes
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**1. Polymers
★ The dehydration reaction responsible for the formation of disaccharides, polysaccharides and oligosaccharides. ★ Classification of glycosidic linkage: ○ α -linkage - The bonds point downward making sugars with this type of linkage digestible for humans (i.e., starch & glycogen). ○ β -linkage - the bonds point upward making sugars with this type of linkage difficult to digest (i.e., cellulose and lactose). POLYSACCHARIDES ★ Polymers with a few thousand monosaccharides formed by glycosidic linkages. ★ Classification of polysaccharides: ○ Storage Polysaccharides ■ Starch - stored sugar in plants. Potatoes, rice and corn are rich in starch. Amylose is the simplest form of starch and it is unbranched. Amylopectin is a more complex starch, and it is a branched polymer. ■ Glycogen - stored sugar in animals. Serves as a temporary energy source and is replenished by eating. ○ Structural Polysaccharides ■ Cellulose - a major component of plant walls that give structural integrity to plants. ■ Chitin - major component of the exoskeletons of arthropods. Present in crustaceans and insects.
★ Carbohydrates that contain 3 to 10 units of monosaccharides. ★ Found in broccoli, peas, and bananas. ★ Functions of oligosaccharides: ○ Prebiotics - oligosaccharides are indigestible by humans. When ingested, they travel to the intestine and serve as prebiotics or fuel for gut bacteria. ○ Cell Marker - oligosaccharides are often attached to lipids and proteins allowing easy identification. Examples include the determination of blood types and distinction between body cells and foreign viruses. Section 3 Lipids LIPIDS ★ Hydrophobic in nature ★ Has hydrocarbon regions with non-polar C-H bonds. ★ Has three main classifications: fats, phospholipids, and steroids. FATS ★ Consists of glycerol joined to three fatty acids. ★ Also called triacylglycerol and triglyceride. GLYCEROL ★ Alcohol. Each of its three hydrocarbons are joined with a hydroxyl group. FATTY ACID ★ Has 16-18 carbon atoms in its skeleton. ★ The carbon at one end of the skeleton is joined to a carboxyl group.
★ Bond between amino acids. ★ A polymer of amino acids is called polypeptide. AMINO ACIDS ★ Building blocks of proteins. ★ An organic molecule with an amino group and a carboxyl group. ★ The 20 amino acids which make up a protein:
Section 5 Nucleic Acid NUCLEIC ACID ★ Also called polynucleotides. ★ A class of compounds which includes genes that contain DNA. ★ These are polymers made up of monomers called nucleotides. DEOXYRIBONUCLEIC ACID ★ Also called DNA. Has deoxyribose. ★ Holds the blueprint for primary protein structure. ★ Inherited genetic material from parent to offspring. RIBONUCLEIC ACID ★ Also called RNA. Has ribose. ★ Builds the protein based on the blueprint provided by DNA. ★ The messenger that translates the genetic instructions in DNA into the primary protein structure. NUCLEOTIDES ★ Composed of pentose, a nitrogenous base and 1-3 phosphate groups. ★ A part of a nucleotide without any phosphate group is called a nucleoside. PYRIMIDINE ★ A family of nitrogenous bases for nucleotides. ★ Has one six-membered ring of carbon and nitrogen atoms. ★ Includes Cytosine , Thymine , and Uracil. PURINE ★ A family of nitrogenous bases for nucleotides. ★ Has one six-membered ring of pyrimidine fused to a five-membered ring of imidazole. ★ Includes Adenine and Guanine. PHOSPHODIESTER BOND ★ The main bond which connects nucleotides to form nucleic acid. SUGAR-PHOSPHATE BACKBONE ★ Repeating pattern of sugar-phosphate units as a result of phosphodiester bond formation. DOUBLE HELIX ★ The winding of two polynucleotides around an imaginary axis. ★ DNA structure. ★ The two strands of a double helix are complementary. CONCEPT: COMPLEMENTARY HELIXES In base pairing, only certain bases in the double helix are compatible with each other. Adenine (A) always pairs with thymine (T) and guanine (G) always pairs with cytosine (C). DNA has adenine, guanine, cytosine, and thymine. RNA has adenine, guanine, cytosine, and uracil. ANTIPARALLEL ★ The two sugar phosphate backbones of DNA run in opposite 5’→3’ directions from each other. ★ The 5’ end is where the phosphate group is attached to the fifth carbon. The 3’ end is where the hydroxyl group is attached to the third carbon.