The Integumentary System, Study notes of Anatomy

An overview of the integumentary system, which includes the skin, hair, and nails. It explains the functions of the skin, such as resistance to trauma and infection, water retention, vitamin D synthesis, sensation, thermoregulation, and nonverbal communication. The document also describes the different layers of the skin, including the epidermis and dermis, and the types of cells found in each layer. Additionally, it discusses the components of the dermis, such as collagen, elastic fibers, and reticular fibers, and the hypodermis, which is the subcutaneous fat layer.

Typology: Study notes

2021/2022

Available from 06/19/2023

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The in tegumentar y system:
This system is composed of the skin and its glands (swe at glands & sebaceous glands), hair, and n ails.
This system provides us w ith clues about one’s hea lth deepe r disorders. Such as live r, cancer, anemia, kidney
dise ase, and hea rt failure .
The sk in is the larges t organ in the bod y.
It is a b arrier t o the o utside world.
Visual indicator of o ur phys iology and health.
Ski n is classifie d as thick (hairless skin) and thin (hairy skin ) depe nding on the thickne ss of t he epidermis alone:
Thick skin:
The pa lm of th e hands and the soles of feet, and su rfaces of the fingers and toe s all h ave thick skin.
it does not have hair follicle s or sebaceous gla nds.
it has all 5 layers of epide rmal strata .
It has swe at glands.
Thin skin:
Covers most of the body
it lacks s tratum lucidum.
It has swe at glands, hair follicles, and se bace ous glands.
Func tions of the skin:
Resistance to trauma and infe ction.
Water re tention
Vit amin D synthes is
Sensat ion
Thermoregulation
Nonverbal communic ation
Major compone nts o f the integumen tar y system:
Cutane ous membrane: ep idermis & dermis. 1.
Subcutaneous : hypodermis . 2.
Access ory structure: hair follicle s, sebaceous and swe at glands, and 3.
sensor y cells (embe dded in t he dermis and pas sing through the
epidermis).
superficial
peep
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The integumentary system:

  • This system is composed of the skin and its glands (sweat glands & sebaceous glands), hair, and nails.
  • This system provides us with clues about one’s health deeper disorders. Such as liver, cancer, anemia, kidney disease, and heart failure.
  • The skin is the largest organ in the body.
  • It is a barrier to the outside world.
  • Visual indicator of our physiology and health. Skin is classified as thick (hairless skin) and thin (hairy skin) depending on the thickness of the epidermis alone: Thick skin:
  • The palm of the hands and the soles of feet, and surfaces of the fingers and toes all have thick skin.
  • it does not have hair follicles or sebaceous glands.
  • it has all 5 layers of epidermal strata.
  • It has sweat glands. Thin skin:
  • Covers most of the body
  • it lacks stratum lucidum.
  • It has sweat glands, hair follicles, and sebaceous glands. Functions of the skin:
  • Resistance to trauma and infection.
  • Water retention
  • Vitamin D synthesis
  • Sensation
  • Thermoregulation
  • Nonverbal communication Major components of the integumentary system:
  1. Cutaneous membrane: epidermis & dermis.
  2. Subcutaneous : hypodermis.
  3. Accessory structure: hair follicles, sebaceous and sweat glands, and sensory cells (embedded in the dermis and passing through the epidermis).

superficial

peep

The Epidermis:

  • The epidermis is composed of multiple layers of cells. Cells types:
  1. Keratinocytes:
  • Most abundant cells in the epidermis. (the main component of the epidermis).
  • Found in all layers. And they synthesize keratin.
  1. Melanocytes:
  • Scattered among the keratinocytes.
  • Produce and store the pigment melanin. It is the pigment that gives skin & hair color.
  • They produce melanin and put those melanosmoes into the keratinocytes around them, so they can have the melanin protection as well.
  • These melanosomes will then accumulate in the keratinocytes, and then it shields the keratinocytes DNA from UV radiation as from the skin.
  1. Langerhans (dendritic cells):
  • cells that prevent things from getting into the skin (immune cells)
  • Often found in stratum spinosum & stratum granulosum.
  1. Tactile cells (tactile discs):
  • Also known as Merkle cells
  • Relatively few in number.
  • They give us a sensitivity to touch.
  • When they are compressed, if something is pushing against your skin, they will release a chemical that stimulate sensory nerve endings. These sensory nerve endings then tranist that impulse to the brain so that your brain knows that you were touched in that spot. There are 5 layers of the epidermis:
  1. Stratum basale:
  • mainly just one layer sometimes t wo.
  • it is the deepest epidermal layer.
  • It can also be called the “stratum germinativum” or basal layer.
  • It is a single layer of cuboidal to low columnar cells.
  • It is attached to the basement membrane, which is the membrane that connect the epidermis with the dermis.
  • It is occupied with three cell types: keratinocytes, melnocytes, and tactile cells (Merkle).
  • In this layer we see a lot of stem cells.
  • These stem cells are able to divide and then regenerate into new cells. (So as you lose cells at the surface of the skin you replace the cells with new ones at the stratum basale. Then they will work their way towards the stratum corneum.
  • Their name comes from the synthesis of a protein called keratin and this protein strengthen the epidermis.
  • It is a tough protein and a little bit elastic.
  1. Stratum spinosum:
  • It is several layers thick.
  • It is also known as the spiny layer, because of the way it appears in the microscope.
  • The cells that were made in the stratum basale (daughter cells) are being pushed into this layer.
  • As they are being pushed into the stratum spinosum they begin to develop into specialized non dividing keratinocytes. These keratinocytes are going to start making a lot of keratin.
  • Now these keratinocytes are attached by structures called intracellular junctions called desmosomes.
  • These desmosomes attach one cell to the next.
  • This layer also contains dendritic cells (Langerhans cells)
  • The are immune cells that will help initiate the immune response ( if there is a pathogen within the epidermis these cells will detect it and then tell the immune system that they need to get rid of it.)

The stratum basal is where you have the stem cells and these are the cells that are going to divide into keratinocytes. The keratinocytes are going to move (up in direction) up through the various layers, until they get to the top. As it moves up they are going to become keratinized and lose their nucleus and organelles, so that at the top spot (*) we have keratinized stratified squamous cells that are completely dead.

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o stemcellsdividing intokeratinocytey dead Keratinocytes. living keratinocytes.

The dermis:

  • Deep to the epidermis.
  • It is composed of primarily connective tissue. Components of the dermis:
  • It is primarily made of collagen with some elastic fibers and reticular fibers. (They are to provide strength and elasticity to the tissue)
  • Also contain motile dendritic cells that serve as an immune function in protection from foreign pathogens.
  • Also had blood vessels, sweat glands (make sweat on the outside of the skin), and sebaceous glands (secret oil for hair).
  • Also contain hair follicles, nail root, sensory nerve endings, arrector pili muscle.
  • The dermis is divided bet ween papillary layer & deeper reticular layer.
  1. The papillary layer:
  • it is a thinner layer.
  • It is the superficial region of the dermis. (Region closest to the surface of the skin)
  • It is directly adjacent to the epidermis
  • It is composed of areolar connective tissue (which is a loose connective tissue)
  • It has dermal papillae that contains capillaries ( blood vessels) and receptors (sensory nerve endings(for things such as touch).
  • Also it has epidermal ridges: which are the projections of the epidermis that arising from the papillae themselves.
  • The papillary layer and the epidermal ridges help to interlock and increase the area of contact bet ween layers
  1. The reticular layer:
  • It is a deeper major portion of the dermis.
  • It is the thick layer.
  • It extends from the papillary layer to the subcutaneous layer (hypodermis).
  • It consists primarily from dense irregular connective tissue.
  • It contain large bundles of collagen fibers.
  • In this layer, we have the hair, the arrector pili muscle, sweat glands, sebaceous glands. Epidermis