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vancomycin ; OTHER NAMES CLASSIFICATION | VANCOCIN Antibiotic - initant INDICATIONS FOR Iv USE HEALTH CANADA APPROVED" ¢ Serious infections dus to betedaciam resistant gram positive microorganisms * Treatment or appropriate prophylaxis of infections caused by gram positive microorganisms in patients allergic to beta- lactam antimicrobials CONTRAINDICATIONS * Hypersensitivity to vancomycin CAUTIONS* » Renal impairment, dose adjustment required « Patients with previous hearing loss PREGNANCY/BREAST FEEDING: Coniact pharmacy for most recent information ADMINISTRATION DIRECT IV INTERMITTENT INFUSION CONTINUOUS INFUSION MORE NO YES NO WHO MAY GIVE All nurses Parlaheral line: Dilute each 500 my in 100-259 mi compatible IV fluid. (260 ml preferred) Max cane. 8 mgfmt. il Central ling: Diiute dose in 25 - 250 mL. compatible IV fluid Infuse doses of 1 g ar lass over at least 60 minutes infuse doses greater than 1 ¢ over ai least 90 minutes PAEDIATRIC See Syringe Pump Infusion Table Undiluted, infuse ever 60 minutes. Recommended emenemala Concentration = 5 mgirmt. 4V infusion device or for outpatients specialized tubing/device designed fo prevent break away, REQUIREMENTS | oq compensating f¥ gravity jlow control device, rate resincuve MONITORING REQUIRED * Monitor peripheral IV site for pain, redness or swelling prier fo initiating infusion and every 30 minutes unti! completion of infusion RECOMMENDED « Advise patients to report buming/stinging/pain at IV site promptly ° Serum creatinine prier to start of therapy and once or twice weekly during therapy ° Serum vancomycin levels if indicated; see THERAPEUTIC DRUG MONITORING RECONSTITUTION e Available as vancomysin 509 mg and 1g vials e Reconstitute vials with SW, NS or DSW. Reconstitution device can be used. Volume of diluent required may vary with brand. See vial for exact volume of diluent and resulling concentration COMPATIBILITY/STABILITY ¢ Stable in dextrose, saline, dextrose-saline combinations, and lactaled Ringers solutions for at least 24 hours at room temperature’ or for 96 hours refrigerated. * Reconstitutsd vials stable at room temperature or refrigerated for 14 days* e For drug-drug compatibility, contact pharmacy ton & references): http:/172.29.12.44Avebbuild/site/wrh- Refer fo WRH Pharmacy Web site for most cusrent ver Sgsec_id=14d59ditem_ id=19420 rev Feb 2011 intranetwebpage.ctn ?site_fd=1&org_id=163&morg_ i 
