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Name: Luisa María Pasaca Benítez
Exercise 9: Renal System Physiology: Activity 2: The Effect of Pressure on Glomerular Filtration Lab Report
Pre-lab Quiz Results You scored 100% by answering 4 out of 4 questions correctly.
- Which of the following forces promotes filtration? You correctly answered: c. blood pressure in the glomerular capillaries
- The glomerular filtration rate can be altered by You correctly answered: b. changing the afferent arteriole resistance.
- In 24 hours human glomerular capillaries can filter as much as __________ liters of filtrate. You correctly answered: c. 180
- Which of the following statements about the filtrate in the renal corpuscle is false? You correctly answered: d. Normally, more than 40% of the blood that enters the glomerular capillaries becomes filtrate.
Experiment Results Predict Question: Predict Question 1: What will happen to the glomerular capillary pressure and filtration rate if you increase the blood pressure in the left source beaker? Your answer : a. Both pressure and filtration rate will increase.
Predict Question 2: What will happen to the filtrate pressure in Bowman's capsule (not directly measured in this experiment) and filtration rate if you close the one-way valve between the collecting duct and the urinary bladder? Your answer : d. Pressure will increase and filtration rate will decrease.
Stop & Think Questions: What is the important relation that underlies the observed increase in glomerular filtration rate when the blood pressure is increased? You correctly answered: c. pressure and flow are directly proportional.
What medical condition is analogous to the closed valve? You correctly answered: b. a tumor obstructing the renal tubule
Experiment Data:
Afferent Radius (mm)
Efferent Radius (mm)
Beaker Press. (mm Hg)
Glomerular Press. (mm Hg)
Glom. Filt. Rate (ml/min)
Urine Volume (ml)
Valve Status
0.50 0.45 70 49.72 58.57 161.76 open 0.50 0.45 80 52.40 91.78 186.23 open 0.50 0.45 90 55.08 124.99 200.44 open 0.50 0.45 100 57.76 158.20 209.72 open 0.50 0.45 70 49.72 58.57 161.76 open 0.50 0.45 70 49.72 26.94 0.00 closed 0.50 0.45 100 57.76 118.20 0.00 closed 0.50 0.45 100 57.76 158.20 209.72 open
Review Sheet Results
- As blood pressure increased, what happened to the glomerular capillary pressure and the glomerular filtration rate? How well did the results compare with your prediction? Your answer: Se predijo adecuadamente dado que la presión sanguínea aumenta y por ende existe un mayor ingresos de sangre hacia los capilares que forman el glomerulo por una unidad de tiempo, va a producir un aumento de presión capilar glomerular como de filtración.
- Compare the urine volume in your baseline data with the urine volume as you increased the blood pressure. How did the urine volume change? Your answer: En los datos obtenidos se puede que mientras se aumentaba la presión arterial, aumentaba a su vez el volumen de orina, esto se da gracias que se dio incialmente el aumento de la presión sanguínea, con lo cual se dio el aumento de la presión capilar glomerular, como resultado se va a dar una mayor difusión en el corpúsculo renal, así, va a haber mayores productos de desecho y con ello aumenta el paso de orina.
- How could the change in urine volume with the increase in blood pressure be viewed as being beneficial to the body? Your answer: Los productos de desecho se eliminan de una forma facil y rápida, no obstante, hay complicacion que se presenta cuando hay un aumento de presión sanguínea y este puede producir problemas mayores como la hipertensión o necesidad de suplir la cantidad de agua que ya ha sido perdida.
- When the one-way valve between the collecting duct and the urinary bladder was closed, what happened to the filtrate pressure in Bowman's capsule (this is not directly measured in this experiment) and the glomerular filtration rate? How well did the results compare with your prediction? Your answer: La presión aumenta sin embargo, la tasa de filtración glomerural disminuyo debido a que se dio el cierre de la valvula de orina que se dirige a la vejiga, por lo tanto no se da el paso normal de la orina, y se obstruye el tracto urinario lo que conlleva a una deficiente retroalimentación de la tasa de filtración
- How did increasing the blood pressure alter the results when the valve was closed? Your answer: Cuando la presión se mantiene constante en ambas situaciones, así cuando la valvula se encuentra abierta como cerrada no produce cambio alguno, y se menciona que la filtración glomerular presenta cambios cuando permane cerrada.
