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A detailed overview of organ systems, including the cardiovascular, nervous, and lymphatic systems. It covers key components such as the heart, blood vessels, neurons, and immune defenses. The guide also explains various processes like blood circulation, nerve signal transmission, and immune responses. It is designed to help students understand the structure and function of different organ systems in the human body, offering a solid foundation for further study in anatomy and physiology. It also includes information about the skeletal and reproductive systems, as well as body planes.
Typology: Lecture notes
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1 | P a g e
Macromolecules : Carbohydrate, Lipid, Nucleic Acid, Protein, Enzyme Carbohydrate: Sugars and starches which body breaks down to glucose ● Structural function: cellulose and chitin ● Energy storage: amylose, amylopectin, glycogen ● Recognition molecules: glycoproteins and glycolipids Lipids: Fatty acids and their derivatives that are soluble in water ● H and C and main components ● Fats ● Hydrophobic- thus help separate aqueous compartments ● Store energy (fats, oils, adipose) Protein: Molecules composed of amino acids joined by peptide bonds ● Monomer: amino acids (amino group + carboxylic acid)(20 types) ● Keratin and Collagen (hydrophobic)- not soluble in water, found in structural protein ● Globular proteins are hydrophilic (hemoglobin, antibodies, enzymes) ● Function as transport carries or signal transfer Nucleic Acids: Long molecules made of nucleotides; DNA and RNA ● DNA stores genetic material ● Chromosomes ● RNA is a messenger (mRNA) also rRNA and tRNA Enzymes: Class of protein that catalyze biochemical reactions ● Not consumed in reaction ● Speed up reaction by lowering activation energy ● Exergonic: release energy ● Endergonic: require energy ● Energy is supplied and released as ATP ● Lock and Key (substrate must fit into enzymes active site) DNA and RNA DNA: macromolecule that contains coded instructions for the body to produce proteins ● Nucleotide: the building block of DNA and RNA ● Nitrogenous Base: Adenine, Thymine, Guanine, and Cytosine ● Purines: Adenine and Guanine ● Pyrimidines: Thymine and Cytosine ● Codon: A group of 3 nitrogenous bases used to synthesize amino acids (Synthesized from RNA during TRANSLATION)
● Hydrogen Bonds: Connect a Purine to a Pyrimidine (A-T) and (C-G). Non-covalent, weak. o RNA: Uracil replaces Thymine ● Double Helix structure ● Coded or read 5'→3' ● Sugar(pentose)-Phosphate backbone (deoxyribose and phosphate group- bound to 4 oxygen atoms) DNA Replication DNA Helicase: Unzips and Unwinds DNA strand DNA Primase: Generates RNA Primer. Act as a template for starting point of DNA Replication DNA Polymerase: Synthesize new DNA molecules by adding nucleotides to leading and lagging DNA strands in 5'→3' direction Topoisomerase: Prevents supercoiling DNA Ligase: Joins DNA fragments together by forming phosphodiester bonds between nucleotides Okazaki Fragment: Short, newly synthesized DNA fragments that are formed on the lagging strand Single Strand Binding Protein: Stabilize structure during replication Leading Strand: Replicated continuously in the 3' to 5' direction Lagging Strand: Replicated discontinuously in short sections
o Anaphase o Telophase o Cytokinesis ● Mitosis = “daughter cell” exact replica o Interphase (G1, S, G2) o Prophase o Metaphase
Cell Cycle ● Meiosis = “daughter cells” different genetic coding o Only happens in gametes* o 1 st^ phase ● chromosomes cross over ● genetic material exchanged ● tetrads of 4 chromatids formed □ Homologous pairs of chromatids are separated and go to different poles □2 cells go through 2nd^ cell division □ 4 daughter cells with different sets of chromosomes ● Haploid : contains half genetic material of parent cell ● Zygote- controls cell differentiation Tissues ¾ groups of cells ¾ Muscle, nerve, epithelial, connective
Organ Systems ¾ groups of organs
i. Secrete sebum
▪ Blood clotting o Plasma ▪ half blood volume ▪ mostly water/ serves as a solvent ▪ contains plasma proteins, ions, glucose, amino acids, hormones, & dissolved gas ● BLOOD VESSELS ● HEART o 4 chambers ▪ each half = atrium & ventricle ● AV valve separates halves o between ventricle & artery leading away from heart ● keep blood moving in single direction o Cardiac cycle ▪ Atrial contraction = fills ventricles ▪ Ventricular contraction = empties ventricles ▪ 1 st^ DIASTOLE PHASE ● Blood flows through superior & inferior venae cavae ● (heart relaxed) atrium □ tricuspid valve □ right ventricle ● SA node (pacemaker wall of right atrium) generates signals (carried by Purkinje fibers) to rest of atrium ● Contracts & fills right ventricle w/ blood ● Impulse from SA node transmitted to ventricle through AV node
● Signals the right ventricle to contract & initiate 1st^ systole phase ▪ 1 st^ SYSTOLE PHASE ● Tricuspid valve closes□ Pulmonary semilunar valve opens ● Blood is pumped out the pulmonary arteries to lungs ▪ 2 nd^ DIASTOLE PHASE ● Blood returning from lungs fills left atrium ● SA node triggers mitral valve to open □ Blood fills left ventricle ▪ 2 nd^ SYSTOLE PHASE ● Mitral valve closes □ Aortic semilunar valve opens ● Left ventricle contracts □ blood is pumped out of aorta to rest of body o Types of Circulation ▪ Coronary : Flow of blood to heart ● Coronary arteries □ aorta (supplying major arteries) □ enter heart w/ oxygenated blood ● Deoxygenated blood returns to right atrium through cardiac veins (empty into the coronary sinus) ▪ Pulmonary : flow of blood between the heart & lungs ● Deoxygenated blood flows from right ventricle to the lungs through pulmonary arteries ● Oxygenated blood flows back to the left atrium through pulmonary veins ▪ (^) Systemic: flow of blood to entire body ● blood exits left ventricle through aorta □ branches into the carotid arteries, subclavian arteries, common iliac arteries, & renal artery ● blood returns to heart through jugular veins, subclavian veins,
a. Growth and development ENDOCRINE FUNCTIONS OF PANCREAS a. Islets of Langerhans i. groups of endocrine cells ii. insulin-producing beta cells and glucagon-releasing alpha cells b. Hormones (pancreas) i. Insulin
▪ substance is released that stimulates or inhibits the actions of adjoining cell ▪ this forms the framework for the nervous system ● FUNCTIONAL TYPES OF NEURONS o 1. Sensory neurons ▪ transmit signals to the central nervous system ● associated with touch, pain, temperature, hearing, sight, smell, & taste o 2. Motor neurons ▪ transmit signals from the CNS to the rest of the body ● signal muscles or glands to respond o 3. Interneurons ▪ transmit signals between neurons ● Neuron Parts o 1. Cell body (soma) ▪ contains nucleus of neuron o 2. Axon ▪ transmits impulses away from cell body ▪ ▪ terminates at the synapse o 3. Dendrites ▪ insulated by oligodendrocytes & myelin sheath with gaps (nodes of Ranvier) receive impulses from sensory receptors or interneurons & transmit them
toward cell body PRIMARY COMPONENTS OF CNS Spinal Cord ● encased in the vertebrae o protects & supports spinal cord ● nervous tissue functions mainly with respect to limb movement and internal organ activity Brain (2 hemispheres / 4 main lobes) Consists of