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This study guide covers key concepts in developmental biology, focusing on the stages of embryogenesis, including fertilization, cleavage, gastrulation, neurulation, and organogenesis. It explains the differences between holoblastic and meroblastic cleavage, various cleavage types (radial, spiral, bilateral, rotational, and discoidal), and the roles of mpf in mitosis. The guide also details body axes and planes, fate maps, von baer's laws, and the embryonic environment, providing a comprehensive overview of early development. It is useful for students studying biology, genetics, and developmental processes, offering a structured approach to understanding the complex mechanisms of embryogenesis. Useful for university students.
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Homunculus - representation of a human being inside reproductive cells at start of development Preformation - debunked concept that an organism's reproductive cells CONTAIN microscopic versions of adults Epigenesis - theory of individual's final form is through a series of progressive changes How was preformation debunked? - use of microscopic studies of chick/egg development proved epigenesis Sperm and Egg cells are - single cells Stages of Embryogenesis - Fertilization, Zygote, Cleavage, Blastula, Gastrulation, Neurula (embryo) Organgenosis, Larval Stages(metamorphosis-some), Maturity Fertilization - fusion of sperm and oocyte (egg) Cleavage - cell division withOUT growth Gastrulation - 3 germ layers form (differentiation) Neurulation - neural tube forms Organogenesis - organs form Larval Stages - gonad development
Maturity - capable of reproduction (gametogenesis) LIfe Cycle of an Organism - Gamete - > Zygote - > Embryo - > Larvae - > Adult Cellular Life Cycle - ONE gamete - > join ONE zygote - > MANY cell embryos - > VERY many cell types Germ Line Concept Cell types - Reproductive cells (sperm and egg) and Somatic Cells (every other body cell) Heritable mutation rates and Germ Line Concept - rates are reliant on when and where the mutation occurs in germ line in either primordial cell or somatic cell Primordial Cell mutations - all gametes will have mutation Somatic Cell mutation - not affect germ line and will NOT be passed on Major Types of Cleavage - Holoblastic AND Meroblastic Holoblastic Cleavage (COMPLETE) types - Isolecithal and Mesolecithal Cleavage Isolecithal Cleavage - Sparse, evenly distributed yolk Isolecithal Cleavage types - Radial, Spiral, Bilateral, Rotational Mesolecithal Cleavage - moderate vegetal yolk disposition Mesolecithal Cleavage types - Displaced radial cleavage
Ventral - belly side Lateral - far from midline Medial - toward midline Anterior (Rostral) - front Posterior (Caudal) - Back Body Axes - Anterior, posterior, dorsal, ventral, lateral, medial Body planes - sagittal, horizontal, transverse Sagittal plane - left and right Horizontal plane - up and down transverse - cross section First body system to develop in verterbrate embryo is - nervous system Fate Map - determine where and what type of cells will be Types of Fate Maps - Vital dye, Fluorescent, Transgenic, Genetic Markers (Lineage) Vital Dye Stain - short lasting dye to alive cells to track
Fluorescent Dye Stain - long lasting and localized; needs special microscope that weakens dye each time used due to light exposure Transgenic DNA method - virus infected into gene to alter with another gene that encodes fluorescent protein development in infected cells Genetic Markers - transgenesis (using some factor present in a cell to another cell and seing if it'll grow) Von Baer's Laws - General features - > Specialized features - > Limbs/Bones appear - > All embryos share similar initial characteristics Embryonic Environment (EE) - conditions experienced that influence survival EE types - External, Internal, E.R.P (environmental regulation pathway) External environment - light, temp, humidity, predators Internal Environment - chemical (hormones, caffeine, nicotine) and competitors (litter-mates) Environmental Rregulation Pathway - external stimulator triggers signaling event in embryo that stimulates embryonic pathway and changes developmental pathway Differentiation - multi step specialization process preceded by commitment Commitment - involves specification and determination Specification - autonomous differentiation when placed in non-neutral ENVIRONMENT (reversible) Determination - autonomous differentiation when placed in a REGION (reversible)