Creative Biostructure's Crystal Batch Screening for High-Quality Crystal Production, Slides of Biology

Download Creative Biostructure's Crystal Batch Screening for High-Quality Crystal Production and more Slides Biology in PDF only on Docsity!

Crystal Batch

Screening

Growth of high-quality crystals is a major obstacle in many structural investigations. In recent years, the techniques for screening crystals have improved dramatically. Creative Biostructure is pioneer in the field of crystals screening, such as peptide crystallization and has led many successful campaigns to produce the crystals in small and large scale. Besides for macromolecular structural study, a crystalline formulation has some advantages over its amorphous counterpart, including: High concentration and high purity: In the crystalline form, the protein molecules exist in the most concentrated form and retain an active conformation; Possibility of controlled release: The dissolution rate in aqueous solution is low relative to the amorphous material. It may be considered as a carrier-free controlled release form; Increased stability: The physical and chemical stabilities of crystalline material may be greater compared to liquid solutions or the amorphous state due to higher purity, more compact molecular arrangement, and restricted molecular motion.

Creative Biostructure uses various leading experimental

packages for advanced crystals screening and production.

We are pleased to inform you the specifications for our

microbatch crystallization service as follows:

1.Non-disclosure agreements can be signed.

2.Crystallization screening of at least 1,000 conditions by

vapor diffusion method including temperatures of 4°C and

20°C.

3.Optimization of crystallization condition by batch method.

4.Large-scale crystal production by batch method.

5.Delivery of large-scale peptide crystals encapsulated in

some conical tubes (15 mL volumes) or plates.

6.Each report should be submitted within 10 days from the

end of each step.

Reference 1.IvanRayment. (2002) Small-Scale Batch Crystallization of Proteins Revisited: An Underutilized Way to Grow Large Protein Crystals. Structure. Pages 147-151. Related Sections Bicelle-Protein Crystallization Co-crystallization Controlled In Meso Phase (CIMP) Crystallization Crystallization Chaperone Strategies Crystallization of Antibody-Antigen Complexes Crystallization with Mutant Library Approaches Lipidic Cubic Phase (LCP) Crystallization Membrane Protein Crystallization Optimization Screening Peptide Crystallization Trace Fluorescent Labeling Crystallization Viral Envelope Glycoprotein Crystallization Crystallography Data Analysis X-ray Diffraction Data Collection

Thank you!

https://www.creative-biostructure.com/

batch-screening-for-crystals-production-

587.htm