MagHelix™ Quartz Crystal Microbalance-Dissipation (QCM-D) Technology for Drug Discovery, Slides of Biology

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MagHelix™ Quartz Crystal Microbalance-Dissipation (QCM-D)

In the early stage of drug development, the process of screening and

characterizing compounds that interact with cellular and protein

targets is essential. Creative Biostructure provides MagHelix™ Quartz

Crystal Microbalance-Dissipation (QCM-D) solutions for drug discovery

departments in the pharmaceutical industry and biotechnology

companies to detect the activity of compounds on specific biological

macromolecular targets or whole cells. QCM-D technology ensures

that the detection process is carried out in a high speed, small sample

quantities, real-time and economical way. Our QCM-D services detect

the kinetics and magnitude of a cell, membrane, and protein drug

targets response with respect to ligand binding, providing a wealth of

information for effective drug screening.

QCM-D technique can sense structural changes in whole cells or molecular

layers on the sensor surface by its ability to probe changes in energy

dissipation, making it potential in drug discovery, both in the screening of

potential pharmaceutical candidates and improve the understanding of

mechanisms of protein-ligand interactions.

Advantages of our MagHelix™ Quartz Crystal Microbalance-Dissipation

(QCM-D) services:

• QCM-D has great advantages in providing binding kinetics information by

virtue of its label-free breadth of applicability, low cost, and sensing unique

mass distribution and viscoelastic behavior aspects of whole-cell responses

in real time.

• QCM-D can also be utilized to analyze the pharmacodynamics and

pharmacokinetics of drugs, such as the detection of drug binding to plasma

proteins.

Creative Biostructure supports the entire process of QCM- D assay development, experimental design, validation, and data analysis. We have many years of experience in the QCM-D project, and we also offer other biophysical techniques to solve the corresponding problems. If you are interested in our hit biophysical characterization solutions, please feel free to contact us.

References 1.Lee H S.; et al. Use of the quartz crystal microbalance to monitor ligand- induced conformational rearrangements in HIV-1 envelope protein gp120. Analytical and Bioanalytical Chemistry. 2010, 396(3): 1143-1152. 2.Campos J.; et al. Quartz crystal microbalance with dissipation monitoring: A powerful tool for bionanoscience and drug discovery. Journal of Bionanoscience. 2015, 9(4): 249-260. 3.Tonda-Turo C.; et al. Quartz crystal microbalance with dissipation monitoring: a powerful method to predict the in vivo behavior of bioengineered surfaces. Frontiers in Bioengineering and Biotechnology. 2018, 6: 158.