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Disorders of Childhood and
Adolescence
Pervasive Developmental Disorders
- Autism Spectrum Disorders: Severe impairment in social interaction and communication skills and display of stereotyped interests and behaviors. - Autistic disorder - Rett’s disorder - Childhood disintegrative disorder - Asperger’s disorder - Pervasive developmental disorders not otherwise specified
Pervasive Developmental Disorders
- Autistic Disorder: Qualitative impairment in:
- Social interaction and/or communication.
- Appears to view other people as just another object.
- Restricted, stereotyped interest and activities
- Delays or abnormal functioning in a major area prior to age 3
- Prevalence: 1:1,000 children, 4-5 times more likely in boys than in girls - ~ 75% have IQ below 70, ~20% are average or above (splinter skills and autistic savants).
Disorders of Childhood and Adolescence Pervasive Developmental Disorders
Pervasive Developmental Disorders Impairments
- Research on social unresponsiveness and unusual communication patterns lends support to clinical observations in some areas: - Autistic children are more interested in inanimate objects than in humans. - Autistic infants don’t engage in social gazing or in pretend play. - Unable to attribute mental states to others or understand thoughts/feelings of others. - Are brutally honest and don’t understand humor.
Pervasive Developmental Disorders Impairments
- Verbal and Nonverbal Communication
- About 50% of autistic children do not develop meaningful speech.
- Oddities such as echolalia often present.
- Reversal of pronouns common, I instead of me or you instead of I.
Pervasive Developmental Disorders Impairments
- Intelligence
- As many as ¾ of children with autism have IQ scores less than 70.
- Some display splinter skills such as drawing, puzzles, or rote memory.
Pervasive Developmental Disorders
- Asperger’s Disorder:
- Significant impairment in social interaction skills, limited and repetitive interests/activities, lack of emotional reciprocity.
- No significant delay in cognitive or linguistic development.
- Subtle difficulties with communication skills.
- Five times more common in males than females.
Pervasive Developmental Disorders
- Pervasive Developmental Disorder Not Otherwise Specified: - Pervasive and severe impairment in reciprocal social interactions, communication abnormalities and limited interests/activities. - Atypical for age of onset/specific behavior patterns
Pervasive Developmental Disorders Autistic Disorders
- Etiology:
- Familial autism
- Autism related to medical condition
- Autism associate with nonspecific brain dysfunction
- Autism without family history or associated brain dysfunction
Pervasive Developmental Disorders Autistic Disorders
- Explanations:
- Family and genetic studies:
- 2-9% of siblings of autistic children have the disorder (100 to 200 times greater than general population).
- Greater for MZ than for DZ twins
- Folstein & Rutter: Diathesis stress model
- 36% concordance rate for identical twins
- In 12 of the 17 discordant MZ twin pairs there was evidence of birth trauma for the affected twin.
Pervasive Developmental Disorders Autistic Disorders
- Explanations:
- Central Nervous System Impairment:
- Brain dysfunction could be inherited.
- Children with autism have higher rates of other chromosomal malfunctions (i.e. pku).
- ¼ to 1/3 of those with autism also have seizures.
- Certain brain structure differences found but no consistent pattern of differences found.