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DNA Mutations Practice Worksheet
DIRECTIONS: Transcribe and translate the original DNA sequence. Then, do the same for each
mutated DNA sequence. Then, determine the consequence, if any, for each mutation, by
circling your choice for each question. You will need a Genetic Code Chart.
Original DNA
sequence:
TAC ACC TTG GCG ACG ACT
mRNA transcript:
amino acids:
Mutated DNA
sequence #1:
TAC ATC TTG GCG ACG ACT
mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation
Mutated DNA
sequence #2:
TAC GAC CTT GGC GAC GAC T
mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation
Mutated DNA
sequence #3:
TAC ACC TTA GCG ACG ACT
mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation
Mutated DNA
sequence #4:
TAC ACC TTG GCG ACT ACT
mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation
Mutated DNA
sequence #5:
TAC ACC TTG GGA CGA CT
mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation
