Randomized Block Design: Accounting for Heterogeneity in Experiments - Prof. Brian C. Denn, Exams of Statistics

The concept of a randomized complete block design (rcbd), a statistical design used in experiments to account for possible heterogeneity in experimental circumstances. The design involves randomly assigning a fixed number of experimental units to each treatment within each block, ensuring that all treatments appear in each block. The statistical model for the rcbd design is presented, along with the estimation of model parameters and hypothesis tests for block and treatment effects. The document also discusses the implications of missing observations and the difference between fixed and random effects models.

Typology: Exams

Pre 2010

Uploaded on 08/19/2009

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Randomized complete block design
Recall 1-way AOV: “completely randomized design with
single factor”. There are experimental units (book is8T
now using notation ), randomly assigned among R>
treatments; objective of study is to obtain inferences about
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Randomized complete block design

Recall 1-way AOV: ìcompletely randomized design with single factorî. There are (^8) Texperimental units (book is now using notation R ), randomly assigned among> treatments; objective of study is to obtain inferences about the treatment means. (^) " ,. (^) # , ..., .>. Reparameterization will be helpful for extending the AOV model to more complicated designs:

! (^) " œ. (^) "'. ! (^) # œ. (^) #'. ã ! (^) > œ. (^) >'.

The! 3 's are the treatment effects ; here .is the overall mean (the mean of the. 3 's) and! (^) " ! (^) # â * !> œ0.

The statistical model becomes

] 34 œ. *! 3 *% 34

where % 34 μ normal 0a ß 5 #b, or equivalently,

] 34 μ normal ˆ^. *! 3 , 5 #‰

The RCBD design incorporates an additional categorical variable, called a blocking variable or block , to account for possible heterogeneity in experimental circumstances. For instance, a typical block in an agricultural experiment is a fieldó fields differ substantially in soil quality, etc., and the same experimental treatment might produce different means in different fields.

Formally, the design is as follows: within each of ,blocks, assign 1 experimental unit at random to each of > treatments. Thus, all treatments appear within each block, and each block-treatment combination receives 1 experimental unit, which produces the observed response C 34 :

block treatment 1 2 , 1 C (^) "" C (^) "# â C (^) ", 'C"† 2 C (^) #" C (^) ## â C (^) #, 'C#† ã ã ã

C (^) >" C (^) ># â C (^) >, 'C>†

mean 'C (^) †" 'C (^) †# 'C†,

The statistical model is

] 34 œ. *! 3 * " 4 *% 34

where D! 3 3 œ 0, D" 4 4 œ 0, and % 34 μ normal 0,a 5 #b. Here

" 4 is the effect of the 4 th block on the mean of ] 34.

The AOV table for the RCBD design:

Source SS df MS J

block SS blocka b , ' " SS block^ a,'^1 b^ MS blockMS erroraa^ bb

trt SS trta b > ' " SS trt>'^ a^1 b^ MS errorMS trta a^ bb

error SS errora b a , ' "ba > ' "b (^) a ,'SS error 1 a^ ba >'b 1 b

total SS totala b ,> ' 1

Hypothesis tests

Block effect

H :! "" œ "# œ â œ ", œ 0 H :a Á

Test statistic is 0 œ MS blockMS error^ aa^ bb using

F a , ' ", a , ' "ba > ' "bbdistribution.

Treatment effect

H :! !" œ !# œ â œ !>œ 0 H :a Á

Test statistic is 0 œ (^) MS errorMS trta a^ bb using F a> ' " , a, ' " ba> ' " bb

distribution.

RCBD remarks

  1. Missing observation(s) produces unbalanced design; block and treatment are no longer orthogonal (& hand- calculating formulas are no longer available). Parameters can still be estimated, and effects tested, in PROC GLM. Use type III sums of squares:

MODEL Y=BLOCK TRT / SS3;

Type III SS tests the effect last, after the other variables are entered in the model.

  1. If blocks have been randomly chosed from some defined population of blocks (block might be a person in a study, say, or a plot of land picked from farms in southern Idaho), one might consider a model in which

" 4 μ normal 0,ˆ^5 "#‰

This is called a random effects model (or, more precisely, a mixed effects model) & the experiment is called a random blocks experiment (rather than randomized block). We will look at a few of these types of models toward the end of the course. The ordinary RCBD model is a fixed effects model.