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ONS ONCC CHEMOTHERAPY
IMMUNOTHERAPY CERTIFICATION LATEST
ACTUAL EXAMINATION 2026 QUESTIONS
WITH DETAILED ANSWERS GRADED A+
⫸ What cells do myeloid precursors turn into? Answer: red blood cells, white blood cells, and platelets ⫸ What cells do lymphoid precursors turn into? Answer: specialized white blood cells called lymphocytes ⫸ Granulocytes are Answer: basophils, eosinophils, neutrophils ⫸ Agranuloyctes are Answer: T lymphocytes, B lymphocytes, monocytes ⫸ What two type of immunity make up the immune system? Answer: innate and adaptive ⫸ What line of defense is innate immunity? Answer: first ⫸ What is the role of innate immunity? Answer: is to mount a non- specific response to a non-self entity that does not retain memory of the entity
⫸ What types of things does innate immunity respond to? Answer: skin, mucous membranes, normal flora of the skin and gut as barrier or bacterial protection against foreign substances AND cellular components such as phagocytes, natural killer cells, granulocytes, and macrophages ⫸ If innate immunity proves to be insufficient, what is mobilized? Answer: adaptive immunity ⫸ Adaptive immunity leads to what? Answer: immune system memory related to a pathogen or foreign substance ⫸ What are the three parts of adaptive immunity? Answer: humoral immunity, cell mediated immunity, regulatory t-cells ⫸ What is humoral immunity made up of? Answer: b lymphocytes, memory b cells, and plasma to produce immunoglobulins or antibodies ⫸ What is cell mediated immunity dependent on? Answer: cytotoxic t- cells, helper t-cells and their cytokines ⫸ What are regulatory t-cells also known as? Answer: supressor t-cells ⫸ What do regulatory t-cells do? Answer: regulate the immune response to prevent autoimmune reactions and limit inflammatory responses
⫸ How do alkylating agents function? Answer: by causing a break in the DNA helix strand, causing interference with DNA replication, which results in cell death ⫸ What are the three most common alkylating agent chemo's? Answer: cytoxan, ifos, bendamustine ⫸ How are alkylating agents and platinum based chemo's different? Answer: platinum based chemo's do not have the molecule to to attach to and destroy DNA ⫸ What are the two most common platinum based chemo's? Answer: cisplatin and carboplatin ⫸ What should you instruct patients to do when receiving oxaliplatin? Answer: to avoid exposure to cold air and consuming cold fluids for 3 to 4 days following treatment ⫸ What are the two most nephrotoxic drugs? Answer: streptozocin and semustine ⫸ What are the most common side effects of antimetabolites? Answer: myelosuppresion, GI toxicities, photosensitivity, hand foot syndrome,
⫸ What kind of chemo therapy require life time doses? Answer: antitumor antibiotics ⫸ What are examples of anthracyclines that? Answer: doxorubicin, daunarubicin, epirubicin, idarubicin ⫸ What are lifetime doses needed for anthrcyclines? Answer: cardiotoxicity ⫸ What are classes of antitumor antibiotics? Answer: anthracyclines and non-anthracyclines ⫸ What are examples of non-anthracyclines? Answer: actinomycin d, mitomycin c, bleomycin ⫸ Why is there a lifetime dose for bleomycin? Answer: pulmonary fibrosis ⫸ Patient's with what diagnosis are more at risk for anaphylaxis to bleomycin? Answer: lymphoma ⫸ How to calculate an ANC Answer: (%polys or segs + %bands) x WBC/ ⫸ What are common plant alkaloids? Answer: etoposide, docetaxol, paclitaxel, vinblastine, vinorelbine
