Pentose Phosphate Pathway: A Detailed Explanation with Medical Implications, Slides of Biochemistry

Download Pentose Phosphate Pathway: A Detailed Explanation with Medical Implications and more Slides Biochemistry in PDF only on Docsity!

Pentose Phosphate Pathway

Also known as:

• Pentose shunt
• Hexose monophosphate shunt• Hexose monophosphate shunt
• Phosphogluconate pathway
• It occurs in the cytosol.

One fate of G6P is the pentose pathway.

Moderate glucose flux

GlycolysisGlycolysis

only

Large glucose flux

Glycolysis

Pentose

Phosphate

Glycolysis PathwayPathway

What does the pentose phosphate

pathway achieve?

• The pathway yields reducing potential in the form of NADPH to be used in anabolic reactions requiring electrons.
• The pathway yields ribose 5-phosphate.• The pathway yields ribose 5-phosphate.
  • Nucleotide biosynthesis leading to: •DNA •RNA •Various cofactors (CoA, FAD, NAD +^ /NADP +^ ).

NADPH is a phosphorylated form of NADH.

In general, with some exceptions, NADH is used to drive theused to drive the phosphorylation of ADP to ATP. NADPH is used where reducing potential is required for synthetic reactions.

The pentose pathway can be divided into two phases.

Non-oxidative interconversion of sugars

Regulatory enzyme

5 carbon atoms

The nonoxidative phase of the

pentose pathway

This entails extensive carbon atom rearrangement.

Transketolase requires the coenzyme thiamine pyrophosphate (TPP), the transaldolase does not.

• Transketolase (TPP) and transaldolase are the link back to glycolysis.
• Glyceraldehyde 3-phosphate
• Fructose 6-phosphate
• Net result:• Net result:

3C 5  2C 6 + C 3