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Pentose Phosphate Pathway- Biochemistry - Lecture Slides, Slides of Biochemistry

Pentose Phosphate, Synthesis of Nadph, Transketolase, Glyceraldehyde, Sedoheptulose, Erythrose, Sedoheptulose, Glyceraldehyde, Fructose, The Dangers of Primaquine are points of this lecture.

Typology: Slides

2011/2012

Uploaded on 11/20/2012

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PENTOSE PHOSPHATE
Pathway
•Glucose-6-PO4 Ribose-5-PO4
•Synthesize NADPH for fatty acid synthesis
•Metabolize pentoses
Take Home: The PENTOSE PHOSPHATE pathway is
basically used for the synthesis of NADPH and D-ribose.
It plays only a minor role (compared to GLYCOLYSIS)
in degradation for ATP energy.
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Download Pentose Phosphate Pathway- Biochemistry - Lecture Slides and more Slides Biochemistry in PDF only on Docsity!

PENTOSE PHOSPHATE

Pathway

• Glucose-6-PO 4  Ribose-5-PO 4

• Synthesize NADPH for fatty acid synthesis

• Metabolize pentoses

Take Home: The PENTOSE PHOSPHATE pathway is basically used for the synthesis of NADPH and D-ribose. It plays only a minor role (compared to GLYCOLYSIS) in degradation for ATP energy.

CHO
C-OH
HO-C
C-OH
C-OH
CH 2 OP
COO-
C-OH
HO-C
C-OH
C-OH
CH 2 OP
C
C-OH
HO-C
C
C-OH
CH 2 OP
O
O

NADP+

NADPH + H+

  • H 2 O

STAGE I (Oxidation)

Glucose-6-PO 4 6-Phosphoglucono-- lactone

6-Phospho- gluconate G-6-P dehydrogenase

Lactonase

CH 2 OH
C-OH
C
CH 2 OP
C=O
HO-
CHO
C-OH
C-OH
CH 2 OP
C-OH
C-OH
C-OH
CH 2 OP
C-OH
HO-C
C=O
CH 2 OH
C-OH
CH 2 OP
CHO

Transketolase

Ribose-5-PO 4 Sedoheptulose-7-PO 4 Xyulose-5-PO 4

Glyceraldehyde-3-PO 4

STAGE III

C-OH
CH 2 OP
CHO
C-OH
C-OH
CH 2 OP
C-OH
HO-C
C=O
CH 2 OH
C-OH
C-OH
CH 2 OP
CHO
C-OH
C-OH
CH 2 OP
HO-C
C=O
CH 2 OH

Glyceraldehyde-3-PO 4

Fructose-6-PO 4

Erythrose-4-PO 4

Transaldolase

Sedoheptulose-7-PO 4

SUMMARY

Xylulose-5-PO 4

Ribose-5-PO 4

Glyceraldehyde-3-PO 4

Fructose-6-PO 4

Erythrose-4-PO 4

Sedoheptulose-7-PO 4

TK
TA
TK

3 Glucose-6-PO 4 + 6 NADP+^ + 3H 2 O

6 NADPH + 6H+ + 3CO 2 + 2 Fructose-6-PO 4

  • Glyceraldehyde-3-PO 4

18 carbons

3 carbons 12 carbons

3 carbons

Note that:

  1. Sedohepulose-7-PO 4 , erythrose-4-PO 4 are strictly intermediates
  2. Fructose-6-PO 4 is never used as an intermediate
  3. Glyceraldehyde-3-PO 4 is both an intermediate and final product
  4. For each glucose oxidized, 2 NADPHs are formed

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