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Pharmacology for January Key points
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drug chemical that causes physiological effect medicine administered to elicit a therapeutic effect toxicology mechanisms by which chemicals produce noxious effects on living tissues or organisms pharmacodynamics how drug affects a living system pharmacokinetics how living systems affects drug pharmacogenetics variations in drug response due to genetic influence pharmacogenomics genetic factors to guide drug therapy pharmacoepidemiology variability of drug response across population pharmacoeconomics comparative cost-to-benefit ratios for treatment strategies pharmacovigilance adverse effects of drugs absorption absorption from the site of administration permits entry of the drug into plasm distribution drug may reversibly leave the bloodstream and distribute into the interstitial and intracellular fluids metabolism the drug may be biotransformed through metabolism by the liver elimination the drug and its metabolites are eliminated from the body in urine, bile, or feces ROUTES OF ADMINISTRATION ICV intracerebroventricular AS left ear AD right ear AU both ears
SL sublingual OS left eye OD right eye OU both eyes PO orally by mouth IO intraosseous IT intrathecal NG nasogastric IP intraperitoneal IV intravenous TD transdermal ID intradermal SC subcutaneous IM intramuscular PR per rectally PV vaginally IU intrauterine IC intracardiac ● Enteral routes ○ Oral ■ Advantages ● Many different dosages ● Possible to reverse ● Different release rates ○ Immediate release ○ Enteric coated ○ Chewable/liquid ○ Extended release/delayed release ■ Disadvantages ● Complex ● First pass metabolism
● Nasal inhalation ○ Can be “topical” to sinus/nasal tissues ○ Can be systemic (naloxene, calcitonin) REVIEW QUIZ SLIDES ALSO!