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BIOC 440 Lecture #4 1
“Protein Structure II. Covalent structures”
I. Protein structure hierarchy.
II. Primary structure of proteins
III. Information content of protein sequences.
• ASSIGNED READIN G: p. 33-36; Se ct 3.2, & Sect. 3.4 (only
p. 92-94 & 102-107 ); p. 378-379.
• Lehninger Web tuto rial: use Web link list ed on BIOC440
Schedule page.
• REVIEW & TEST yo urself online (use We b link listed on
BIOC440 Sc hedule page and try P robs. 1, 2, 5, 9, 11 , 12.)
• HOMEWORK PROBLEM SET #2
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The
function
of a protein can best be understood
in terms of its
structure
.
• FOUR levels of structural organization:
Primary
Secondary
Tertiary
Quaternary
Fig. 3-23
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Protein Primary (covalent) Structure
• proteins are polymers of AMINO ACIDS
• functional proteins consist of:
• not
ALL
sequences exist in nature
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Protein Sequence Nomenclature
• directionality or polarity
• numbering convention
• “residue”
