Zebrafish Screening Platform
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MagHelix™ Zebrafish Platform: Comprehensive Tool for Medical Research & Drug Discovery, Slides of Biology
The MagHelix™ Zebrafish Screening Platform is a cutting-edge research tool developed by Creative Biostructure for medical research and drug discovery. Zebrafish, with its high genetic homology to humans and ease of manipulation, is an excellent model organism for studying various diseases and screening novel drugs. The platform offers advantages such as non-invasive imaging, short experiment period, and permeability to small molecules. It includes morphological, behavioral, fixed time-point/labeling, and fluorescence assays for identifying endpoints of toxicity and elucidating mechanisms of toxicity. Applications range from cardiovascular toxicity tests to neurological disorder models.
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2019/2020
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Zebrafish Screening Platform
MagHelix™ Zebrafish Screening Platform
Zebrafish ( Danio rerio ) possesses the
physiology complexity of mammalian
animals and is one of the most common
vertebrate model organisms. Creative
Biostructure establishes the MagHelix™
Zebrafish Screening Platform for medical
research. Zebrafish is an excellent choice to
model various diseases and screen novel
drugs for medical and therapeutic
research. Zebrafish larvae have been used
increasingly within the last decade to assess
the effects of chemical compounds.
There are four classes of zebrafish chemical screening assays:
Morphological screens (to screen chemical genetics and toxicology)
Behavioral screens (ex. using swimming kinetics to quantify the effects of single
compounds)
Fixed time-point/labeling assays (to obtain information on a cellular or tissue level)
Fluorescence assays (reporter-based quantifications)
Introduction to MagHelix™ Zebrafish Screening Platform
Using the zebrafish as animal model is the feature of this platform. The main
research fields of the platform are: 1) Generating multiple transgenic zebrafish
models for human disease; 2) Research and development of drug candidates based
on screening results.
There are various assays based on MagHelix™ Zebrafish Screening Platform shown
in the following table. Take the cardiovascular toxicity test as an example, which is a
key limiting factor in drug discovery. One of the features that the zebrafish heart can
be dissected rapidly and maintained ex vivo for several days makes zebrafish an
excellent model for assessment of cardiovascular toxicity.
Angiogenesis assay
mRNA expression marker (Each gene)
Toxicity tests
General toxicity on survival rates of
zebrafish embryo or larvae
Cardiotoxicity test in zebrafish
Toxicity test to development of motor
neuron or dopaminergic neuron in
zebrafish
Human Endothelial Cell (HUVEC) model
Proliferation assay
Adhesion assay
Migration assay
Tube formation assay
Cardiovascular disease model
Protective effect against chemotherapy drug-induced
cardiac damage in zebrafish
Protective effect against chemical-induced cerebral
hemorrhage in zebrafish
Skeletal disease model Bone anabolic effect in zebrafish
Immunological model Immunosuppressive effect on T-cell in zebrafish
Creative Biostructure welcomes global academic institutions, biotechnology, and
pharmaceutical industries to utilize our MagHelix™ Zebrafish Screening Platform to evaluate the
activity and toxicity of compounds for drug development.