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Pavlov's theory of classical conditioning through the example of respondent conditioning and its application to anticipatory nausea and vomiting in the context of chemotherapy. The document also discusses the differences between respondent and operant conditioning, and provides an example of a study on classical conditioning of decreases in human systolic blood pressure.
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Respondent Conditioning Based on Pavlovโs work on the salivary reflex in dogs Also known as Pavlovian or Classical conditioning Based on physiological responses to environmental stimulation Contingency: Relationship between antecedent stimuli Definition: Process whereby a previously neutral stimulus elicits a response due to pairing of the neutral stimulus with an unconditioned eliciting stimulus Respondent Conditioning Paradigm Before conditioning: Unconditioned stimulus (US) ๏ Unconditioned response (UR) Meat powder ๏ Salivation During conditioning: Neutral stimulus (NS) + (US) ๏ Unconditioned response (UR) Metronome + Meat powder ๏ Salivation (UR) Following conditioning: Conditioned stimulus (CS) ๏ Conditioned response (CR) Metronome ๏ Salivation (CR) Extinction: Repeated CS presentations ๏ Disappearance of CR Metronome ๏ No salivation An Example Scenario: A patient goes to clinic to receive chemotherapy for cancer (the 4th session out of a 12-session course). As the patient enters the waiting room, she begins to feel nauseous and she vomits. Upon questioning, the patient says "I get queasy on my chemo day." This scenario recurs a few more times, until the patient drops out of therapy Responses of interest: Anticipatory nausea & vomiting Dropping out of therapy Anticipatory Nausea & Vomiting (ANV) Initial therapy sessions: Chemotherapy (US) ๏ Post-chemotherapy nausea and vomiting or โPCNVโ (UR) But: A number of stimuli (NS) are paired with US Eg: Wait room + chemotherapy ๏ PCNV Later therapy sessions: See nurse (CS) ๏ ANV (CR) Wait room (CS) ๏ ANV (CR) Parking lot (CS) ๏ ANV (CR) Smell coffee (CS) ๏ ANV (CR) Perfume (CS) ๏ ANV (CR)
Dropping out of Therapy Antecedent Event ๏ Response ๏ Consequence Chemotherapy day ๏ Go to clinic ๏ Chemotherapy (PCNV, ANV) Chemotherapy day ๏ Stay home ๏ Avoid nausea (Sr-) Respondent vs. Operant Conditioning Similarities: Both processes involve Learning produced by environmental contingencies Responding controlled by antecedent stimuli Difference between respondent and operant contingencies: Respondent Conditioning: Pairing of antecedent stimuli (NS ๏ US), one of which (US) already elicits a response, which produces: CS ๏ CR Operant Conditioning: Pairing of response and consequence (R ๏ Sr), which occurs in presence of antecedent stimuli that may acquire discriminative properties, which produces: SD^ ๏ R ๏ Sr