High-Res NMR for Characterizing Solid Materials, Slides of Biology

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Solid-state NMR Services

X-ray crystallography, nuclear magnetic resonance (NMR) and Cryo-

electron microscopy (Cryo-EM) are three of the most predominant

techniques in structure biology. They are powerful tools that help

structural biologists get an insight into the bioprocess mechanism. NMR

is a non-destructive method which providess information on chemical

structure and dynamics with atomic resolution. Unlike solution-state

NMR, which is good at resolving small protein structure and obtaining

dynamic information of soluble materials, solid-state NMR (ssNMR) is a

powerful technique for the characterization of solid materials. With

solid-state NMR methods, information about structure symmetry,

dynamics, and interactions of molecules and complexes can be

obtained.

With superior expertise on NMR spectroscopy, Creative Biostructure

provides high quality solid-state NMR services for analysis of

pharmaceutical molecules, polymers, glasses, and biosolids. Our featured

one-stop service covers every step from sample preparation to data

collection and analysis.

At Creative Biostructure, the following solid-state NMR experiments can

be performed:

Experiments using magic-angle spinning (MAS) with a suitable rotor and

NMR probe.

1D NMR experiments with C-13, F-19, P-31 and many more nuclei.

2D experiments such as MQMAS, REDOR, TRAPDOR.

Reference:

Jean-Philippe Demers, Pascal Fricke et. al. Structure Determination of

Supra-Molecular Assemblies by Solid-State NMR: Practical

Considerations. Prog Nucl Magn Reson Spectrosc , 2018;109:51-78.

Related Sections

Membrane Protein Structure Determination by Solid-state NMR