High-Resolution Solid-State NMR Services for Material Characterization, Slides of Biology

Download High-Resolution Solid-State NMR Services for Material Characterization and more Slides Biology in PDF only on Docsity!

Solid-state NMR Services

X-ray crystallography, nuclear magnetic resonance (NMR) and Cryo-electron microscopy

(Cryo-EM) are three of the most predominant techniques in structure biology. They are

powerful tools that help structural biologists get an insight into the bioprocess

mechanism. NMR is a non-destructive method which providess information on chemical

structure and dynamics with atomic resolution. Unlike solution-state NMR, which is good

at resolving small protein structure and obtaining dynamic information of soluble

materials, solid-state NMR (ssNMR) is a powerful technique for the characterization of

solid materials. With solid-state NMR methods, information about structure symmetry,

dynamics, and interactions of molecules and complexes can be obtained.

With the recent development of the solid-state NMR technique, high-resolution spectra

can be obtained in combination of of cross polarization (CP) and magic angle spinning

(MAS) techniques. Besides, solid-state NMR is a powerful and complementary tool to

Raman and X-Ray Diffraction (XRD) for polymorph characterization.

With superior expertise on NMR spectroscopy, Creative Biostructure provides high

quality solid-state NMR services for analysis of pharmaceutical molecules, polymers,

glasses, and biosolids. Our featured one-stop service covers every step from sample

preparation to data collection and analysis.

At Creative Biostructure , the following solid-state NMR experiments can be performed:

Experiments using magic-angle spinning (MAS) with a suitable rotor and NMR probe.

1D NMR experiments with C-13, F-19, P-31 and many more nuclei.

2D experiments such as MQMAS, REDOR, TRAPDOR.

Creative Biostructure promises to work closely with our customers to provide excellent

services from sample preparation to ssNMR data collection and analysis. We aim for

providing our customers with the highest quality NMR data.

Membrane protein structure determination by solid-state NMR

Please feel free to contact us for a detailed quote.

Reference:

1.Jean-Philippe Demers, Pascal Fricke et. al. Structure Determination of Supra-Molecular Assemblies by

Solid-State NMR: Practical Considerations. Prog Nucl Magn Reson Spectrosc , 2018;109:51-78.

Related Sections

Services:

• Chemical Composition Determination
• Isotope Labeled Protein Production
• Compound Structure Determination
• MagHelix™ Drug Design
• NMR Analysis for Biopharmaceutical Development