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Serologic Testing in Connective Tissue Diseases: An Overview of Associated Autoantibodies, Lecture notes of Human Biology

Ajman University of Science & Technology (AUST)Human Biology

This table provides an overview of various autoantibodies and their associations with different connective tissue diseases, including systemic lupus erythematosus, sjögren syndrome, systemic sclerosis, rheumatoid arthritis, and mixed connective tissue disease.

Typology: Lecture notes

2021/2022

Uploaded on 09/07/2022

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Table II. Serologic testing in Connective tissue disease
Autoantibody
Serology Type
Connective Tissue Disease Association
dsDNA
Anti-dsDNA
antibody
Systemic lupus erythematosus
SSA
Anti-Ro antibody
Systemic lupus erythematosus, SS, myositis
SSB
Anti-La antibody
Sjögren syndrome (~15% in systemic lupus
erythematosus)
Scl-70
Anti-DNA
topoisomerase 1
Systemic sclerosis
CCP
Anti-CCP
antibody
Rheumatoid arthritis
RF
Rheumatoid factor
Rheumatoid arthritis
RNP
Anti-U1 small
nuclear RNP
Mixed connective tissue disease
Jo-1, EJ, PL7
Anti-tRNA
Dermatomyositis/polymyositis/antisynthetase
syndrome
!

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Table II. Serologic testing in Connective tissue disease Autoantibody Serology Type Connective Tissue Disease Association dsDNA Anti-dsDNA antibody Systemic lupus erythematosus SSA Anti-Ro antibody Systemic lupus erythematosus, SS, myositis SSB Anti-La antibody Sjögren syndrome (~15% in systemic lupus erythematosus) Scl- 70 Anti-DNA topoisomerase 1 Systemic sclerosis CCP Anti-CCP antibody Rheumatoid arthritis RF Rheumatoid factor Rheumatoid arthritis RNP Anti-U1 small nuclear RNP Mixed connective tissue disease Jo-1, EJ, PL7 Anti-tRNA Dermatomyositis/polymyositis/antisynthetase syndrome