laminas tema 2, Apuntes de Fisiología

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TEMA 2. DOLOR.- Características.- Mecanismos periféricos.- Neuroanatomía.- Control del dolor.- Efecto placebo. o Chile rojo CHjo. 4. Algunos pimientos populares que contienen capsaicina, B, Estructura química de la capocicina. O. Molécula e la capsacina. D. Diagrama del canal de receptor de VR-l/capsaicina. Est canal puede ser activado por capenician intercelulanmente o por calor o protones (+) en la superficio celular "y is S) sonatas To sssocation 118) Habañiero Sustancia P Sistema. anterolateral Patata etiralar Sorslcor Colfateral projectiol from the ascending tracts innervate the parabrachial region (P8), the mesencephalis reticular formation and the perlaqueducial gray (PAG) as well. The ascending noci i ceptive inputs activate a cascade of descending paín inhibiton, | (blue) and faciltatory (red) circults that modulate further noxious | inputs. The somatosensory cortex, thalamus, and limbic region: communicate win one another, and wih Me PAS, Which S< n predominant pain-inhibitory locus with reciprocal communication: | with th rostroventromedial medulla (RVM). Inhibitory signals ari | also elicited irom noradrenrgic nuclear, meluding the A7, AS, aru locus eoeruleus (LC), which may project directly to 168 Epinal cor | Gr through ths AVM. Descending pain tacilitatory signals ma ; arise trom the anterior cingulate cortex (ACC), which communi | cates with limbic siructures as wellas Me AVM. The parabrachia l region (PB) and the dorsal reticular nucleus (DRT) also activate | ==>) | Pain-tacilfatory signals, enhar diraciy to this Spinal dorsal horn.o | via synaptic transmission in the AVM. The RVM acts as a fina 5 Or | relay tor the integration of descending pain modulatory systems. | Res: p onsé recelves inputs from rosiral structures and possesses both prono Ñ ciceptive facilitatory and antinociceptive inhibitory projections the spinal dorsal hom. The predominant net eifect eliher inhibtt: Turther noxíous inputs, thus serving as an endogenous antinoci A ! captive system, or facilitates nociceptive inputs, thus acting as : : pronociceptivo modulatory system that promotes states C anhanrar nain DRG dorsal root aanalion. 2