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Una introducción detallada a las neuronas, las células especializadas del sistema nervioso que reciben estimulos sensoriales y transmiten respuestas a los órganos effectores. Aprenderemos sobre su composición, funciones y clasificación, incluyendo el papel de los axones y dendritas, la formación de sinapsis y el desarrollo de neuronas. Además, se abordarán temas relacionados como el sistema nervioso periférico y el sistema nervioso central.
Tipo: Apuntes
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Gray matter- The nervous tissue which appears gray. It is grey due to rich blood
supply and absence of myelin. It has rich blood supply because it contains cell
bodies of the neuron.
Composition:
**1. Cell bodies of neurons
White matter- The nervous tissue which appears white. It is white due to presence
of myelin and less blood supply. It has less blood supply because it does not
contain cell bodies of the neuron.
Composition:
**1. Distal myelinated portion of axons
Organization of gray and white matter-
and spinal cord.
and cerebellum.
According to polarity (number of neurites)/morphological classification-
Dorsal Root Ganglion, neurons of sensory cranial ganglia, neurons of mesencephalic
nucleus of trigeminal nerve.
cells, neurons of vestibular (Scarpa’s ganglion) and cochlear (spiral) ganglion.
pyramidal cells of cerebral cortex, Purkinje cells of cerebellar cortex, interneurons,
neurons of autonomic ganglia..
Neuron doctrine: by Ramon y Cajal- 6 tenets
in 1 sentence
Neuron is the anatomical, genetic, functional, polarized,
pathologic and regenerative unit of nervous system.
Structure of a neuron:
Dendrites
Soma
Axon hillock
Axon
Axon terminal
Organelles (mitochondria, Endoplasmic
Reticulum, etc)
Nucleus
Microtubules
cytoskeleton, are red. The cytoskeleton is responsible for intracellular transport, structure and motility of the cell, as
well as segregating the chromosomes during nuclear division. Lysosomes, vesicles that contain enzymes for breaking
down waste materials, are green.
Axonal flow has a slow and a fast component , 0~2 8~0mm and between 50
500 mm per day respectively. Fast axoplasmic flow carries organelles,
including vesicles and mitochondria, and membrane bound substances like
proteins and neurotransmitters materials which are essential for synaptic
activity. The fast axonal flow is effected by microtubules, but the possibility
that some membrane bound proteins are transported by the smooth
endoplasmic reticulum Or another tubulo vesicular system cannot be excluded.
Slow flow, in contrast, transports high molecular weight and soluble materials
which are involved in the growth and maintenance of the axon. The structural
basis of slow transport is controversial, but the movement of the cytoplasmic
matrix itself may represent the prime force. Mechanisms of anterograde and
retrograde transport are similar: both need metabolic energy, have similar
ionic requirements and are sensitive to the same drugs. Both anterograde and
retrograde transport can be blocked by low temperatures and suspended by
colchicine and vinblastine, agents which disrupt microtubules.
Microscopy with
Fluorescent Proteins Microscopy with
Fluorescent Proteins
Murthy_HHMI_teachers_2005_sub.ppt