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Neuronas: Función, Composición y Clasificación - Prof. Uceda, Apuntes de Psicología

Una introducción detallada a las neuronas, las células especializadas del sistema nervioso que reciben estimulos sensoriales y transmiten respuestas a los órganos effectores. Aprenderemos sobre su composición, funciones y clasificación, incluyendo el papel de los axones y dendritas, la formación de sinapsis y el desarrollo de neuronas. Además, se abordarán temas relacionados como el sistema nervioso periférico y el sistema nervioso central.

Tipo: Apuntes

2016/2017

Subido el 02/06/2017

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Tema 4. La neurona
Main references:
-1. Notas del profesor.
- 2. Carlson. Physiology of Behavior. Chapter 2 and
4.
-3. Agueda del Abril y cols. Fundamentos de
Psicobiología, Capítulo 6. Epígrafe: Células del
sistema Nervioso Central. Y Capítulo 10. Bases d la
Comunicación Neuronal.
- 4. Cuadernos de mente y cerebro, número 1. Las
neuronas
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Tema 4. La neurona

Main references:

-1. Notas del profesor.

- 2. Carlson. Physiology of Behavior. Chapter 2 and

-3. Agueda del Abril y cols. Fundamentos de

Psicobiología, Capítulo 6. Epígrafe: Células del

sistema Nervioso Central. Y Capítulo 10. Bases d la

Comunicación Neuronal.

- 4. Cuadernos de mente y cerebro, número 1. Las

neuronas

Gray matter- The nervous tissue which appears gray. It is grey due to rich blood

supply and absence of myelin. It has rich blood supply because it contains cell

bodies of the neuron.

Composition:

**1. Cell bodies of neurons

  1. Dendrites and proximal/initial (non-myelinated) portion of axons
  2. Supporting cells-neuroglia
  3. Blood vessels (abundant)**

White matter- The nervous tissue which appears white. It is white due to presence

of myelin and less blood supply. It has less blood supply because it does not

contain cell bodies of the neuron.

Composition:

**1. Distal myelinated portion of axons

  1. Supporting cells-neuroglia
  2. Blood vessels (few)**

Organization of gray and white matter-

  • (^) Primitive organization-inner gray matter, outer white matter- e.g. Brain stem

and spinal cord.

  • (^) Modified organization-outer gray matter, inner white matter- e.g. Cerebrum

and cerebellum.

2 types of peripheral nerves-

1. CRANIAL NERVES - 12 pairs-Nerves attached to brain.

2. SPINAL NERVES - 31 pairs-Nerves attached to spinal cord.

Cranial nerve may be pure motor , pure sensory or mixed (both motor

& sensory).

Spinal nerve is always mixed.

Motor nerve contains only efferent ( outgoing ) fibers.

Sensory nerve contains only afferent ( incoming ) fibers.

Mixed nerve contains both efferent ( outgoing ) fibers & afferent

( incoming ) fibers.

Classification of neurons:

According to polarity (number of neurites)/morphological classification-

1. Unipolar (pseudounipolar) neurons- Functionally sensory neurons. E.g. Neurons of

Dorsal Root Ganglion, neurons of sensory cranial ganglia, neurons of mesencephalic

nucleus of trigeminal nerve.

2. Bipolar neurons- Functionally sensory neurons. E.g. Bipolar neurons of retina, olfactory

cells, neurons of vestibular (Scarpa’s ganglion) and cochlear (spiral) ganglion.

3. Multipolar neurons- Functionally motor neurons. E.g. Anterior horn cells of spinal cord,

pyramidal cells of cerebral cortex, Purkinje cells of cerebellar cortex, interneurons,

neurons of autonomic ganglia..

Other types:

1. Amacrine neurons

2. Microneurons (7μM)

3. Paraneurons (apolar neurons). Embryos

Locations of neurons (cell bodies):

1. Within gray matter of CNS

2. Within white matter of CNS as nuclei

3. Within peripheral ganglia

4. Within olfactory epithelium, retina

Development of neurons:

1. CNS neurons- from neural tube

2. Neurons of peripheral ganglia- from

neural crest and ectodermal placodes

Neuron doctrine: by Ramon y Cajal- 6 tenets

in 1 sentence

Neuron is the anatomical, genetic, functional, polarized,

pathologic and regenerative unit of nervous system.

Structure of a neuron:

Dendrites

Soma

Axon hillock

Axon

Axon terminal

Organelles (mitochondria, Endoplasmic

Reticulum, etc)

Nucleus

Microtubules

  • (^) Credit: ROBERT MCNEIL, BAYLOR COLLEGE OF MEDICINE / SCIENCE PHOTO LIBRARY
  • (^) Caption: Cell structure. Fluorescent light micrograph of a neuron (nerve cell). Microtubules, part of the cells'

cytoskeleton, are red. The cytoskeleton is responsible for intracellular transport, structure and motility of the cell, as

well as segregating the chromosomes during nuclear division. Lysosomes, vesicles that contain enzymes for breaking

down waste materials, are green.

Axonal flow has a slow and a fast component , 0~2 8~0mm and between 50

500 mm per day respectively. Fast axoplasmic flow carries organelles,

including vesicles and mitochondria, and membrane bound substances like

proteins and neurotransmitters materials which are essential for synaptic

activity. The fast axonal flow is effected by microtubules, but the possibility

that some membrane bound proteins are transported by the smooth

endoplasmic reticulum Or another tubulo vesicular system cannot be excluded.

Slow flow, in contrast, transports high molecular weight and soluble materials

which are involved in the growth and maintenance of the axon. The structural

basis of slow transport is controversial, but the movement of the cytoplasmic

matrix itself may represent the prime force. Mechanisms of anterograde and

retrograde transport are similar: both need metabolic energy, have similar

ionic requirements and are sensitive to the same drugs. Both anterograde and

retrograde transport can be blocked by low temperatures and suspended by

colchicine and vinblastine, agents which disrupt microtubules.

Review the Synapse

• What is a synapse?

• A synapse is the “gap” between the axon of

one nerve and the dendrite of the next one.

• The average neuron has 1,000 synapses

with other neurons.

What does a synapse look like?

Electron Micrograph

Microscopy with

Fluorescent Proteins Microscopy with

Fluorescent Proteins

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