Involucrin is a protein component of human
skin and in humans is encoded by the IVL
gene.[3][4] In binding the protein loricrin,
involucrin contributes to the formation of a cell
envelope that protects corneocytes in the skin.
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Involucrin
‹ The template Infobox gene is being considered for merging. ›
IVL
Available structures
PDB Human UniProt search: PDBe RCSB
List of PDB id codes
1EU0
Identifiers
Aliases IVL, involucrin
External IDs HomoloGene: 136793
GeneCards: IVL
Gene location (Human)
Chr. Chromosome 1 (human)[1]
Band 1q21.3 Start 152,908,545 bp[1]
End 152,911,886 bp[1]
RNA expression pattern
More reference expression data
Gene ontology
Molecular
function
• protein binding, bridging
• protein binding
• structural molecule activity
Cellular
component
• cytoplasm
• extracellular exosome
• cornified envelope
• centrosome
• cytosol
• nuclear body
Biological
process
• response to UV-B
• peptide cross-linking
• keratinization
• isopeptide cross-linking via N6-
(L-isoglutamyl)-L-lysine
• keratinocyte differentiation
• cornification
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez
3713
n/a
Ensembl
ENSG00000163207
n/a
UniProt
P07476
n/a
RefSeq
(mRNA)
NM_005547
n/a
RefSeq
(protein)
NP_005538
n/a
Location
(UCSC)
Chr 1: 152.91
– 152.91 Mb
n/a
PubMed
search
[2] n/a
Wikidata
View/Edit Human
Involucrin of squamous epithelia N-
terminus
Identifiers
Symbol Involucrin_N
Pfam PF10583
InterPro IPR019571
Available protein structures:
Pfam structures
PDB RCSB PDB ; PDBe ;
PDBj
PDBsum structure summary
Involucrin repeat
Identifiers
Symbol Involucrin
Pfam PF00904
InterPro IPR000354
SCOP 1eu0
SUPERFAMILY 1eu0
Available protein structures:
Pfam structures
PDB RCSB PDB ; PDBe ;
PDBj
PDBsum structure summary
Involucrin repeat
Identifiers
Symbol Involucrin2
Pfam PF06994
InterPro IPR009733
Available protein structures:
Pfam structures
PDB RCSB PDB ; PDBe ;
PDBj
PDBsum structure summary
Gene
Function
Clinical significance
Structure
References
Further reading
Last edited 2 years ago by KolbertBot
08/04/2019, 11*04
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