BIOS 255 Week 1 Assignment; Case Study - Coagulation, Papers of Biology

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Week 1 Case Study: Coagulation Chamberlain University BIOS 255- Student Name Date

Discuss which clotting factors the PT and PTT test evaluate and whether each test measures the intrinsic or the extrinsic pathways. According to this website, “The PTT assesses the amount and the function of certain proteins in the blood called coagulation or clotting factors that are an important part of blood clot formation” (Expert Board, 2021). The clotting factors for a PT test include VII, X, V, II, and I (fibrinogen). This test measures the extrinsic pathways. As for PTT, this test evaluates factors XII, XI, VIII, IX and measures intrinsic pathways. Describe the common coagulation pathway. The common coagulation pathway consists of a series of events that all lead up to hemostasis. The two paths known as extrinsic and intrinsic, happen at separate times but come together at a certain point leading to fibrin activation. The common pathway factors consist of factors I, II, V, VIII, X. This pathway begins at factor X, which is then activated to factor XA. Once XA is activated, prothrombin and then thrombin are activated. Based on Jessie’s test, which factor deficiency do you believe he has and why? Based on Jessie’s test, I believe he has a deficiency in the intrinsic pathway. Reason being, the tests included in a PTT are XII, IX, XII, and XI. If any of these