Zebrafish: A Valuable Model for Human Disease Research and Drug Discovery, Slides of Biology

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disease modeling in zebrafish

Zebrafish has been widely used as an ideal model to find genes involved in

specific processes and/or check the activity of a desired gene in a specific

process. Over the last decade, it has also been developed into a valuable

system for the study and modeling of various human diseases, as well as

the discovery of relevant drug candidates. The development and

functionality of zebrafish organs are essentially similar to those of humans;

and the ease of genetic modifications has further facilitated the

generation of disease models in the zebrafish system. Fish and humans

share high functional similarities in a group of genes involved in

physiological processes. The zebrafish model plays an important role in the

understanding of human disease pathogenesis and ultimately the

discovery of new therapeutic agents for a wide range of human diseases.

Creative Biostructure provides expertise in transgenic

manipulation in zebrafish model for human disease modeling and

validation, as well as targeted drug screenings. With previously

acquired knowledge, a powerful genome editing technology has

been developed based on our zebrafish screening platform.

Our Disease Model Generation Services include:

Null mutant:

A complete knock out line will be generated by disrupting the

coding frame.

Custom mutant:

The desired coding modification will be introduced to generate a

genetic version mimicking a human polymorphism.

Advantages of our Disease Model Generation services:

Our aim is to generate, validate, and use of selected zebrafish disease

models for novel drug discovery or other applications.

We have established an advanced zebrafish platform to support

disease modeling and in vivo drug screening.

With outstanding expertise and an experienced team of scientists, we

have the ability to generate targeted zebrafish models to accelerate the

research of a wide range of scientific topics.

The scientists in our drug discovery team customize the solution

according to the project requirements, follow up the procedure, and are

responsible for interpreting the results.

We strictly keep the project information and experimental data

confidential.