Zebrafish Disease Modeling: Identifying Genetic & Chemical Modifiers of Human Diseases, Slides of Biology

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disease modeling in zebrafish

Zebrafish has been widely used as an ideal model to find genes involved in

specific processes and/or check the activity of a desired gene in a specific process.

Over the last decade, it has also been developed into a valuable system for the

study and modeling of various human diseases, as well as the discovery of

relevant drug candidates. The development and functionality of zebrafish organs

are essentially similar to those of humans; and the ease of genetic modifications

has further facilitated the generation of disease models in the zebrafish

system. Fish and humans share high functional similarities in a group of genes

involved in physiological processes. The zebrafish model plays an important role

in the understanding of human disease pathogenesis and ultimately the discovery

of new therapeutic agents for a wide range of human diseases.

Creative Biostructure provides expertise in transgenic manipulation in zebrafish model for human

disease modeling and validation, as well as targeted drug screenings. With previously acquired

knowledge, a powerful genome editing technology has been developed based on our

zebrafish screening platform.

Our Disease Model Generation Services include:

Null mutant:

A complete knock out line will be generated by disrupting the coding frame.

Custom mutant:

The desired coding modification will be introduced to generate a genetic version mimicking a

human polymorphism.

Advantages of our Disease Model Generation services:

Our aim is to generate, validate, and use of selected zebrafish disease models for novel drug

discovery or other applications.

We have established an advanced zebrafish platform to support disease modeling and in

vivo drug screening.

With outstanding expertise and an experienced team of scientists, we have the ability to

generate targeted zebrafish models to accelerate the research of a wide range of scientific topics.

The scientists in our drug discovery team customize the solution according to the project

requirements, follow up the procedure, and are responsible for interpreting the results.

We strictly keep the project information and experimental data confidential.

Creative Biostructure can model diseases in the zebrafish, providing a convenient and powerful

platform in which genetic and/or chemical suppressors and/or enhancers of the disease

phenotype can be identified and studied.

Reference

1.Santoriello C, Zon L I. Hooked! Modeling human disease in zebrafish. The Journal of clinical

investigation. 2012, 122(7): 2337-2343.

2.Kiper K G, Freeman J L. Zebrafish as a tool to assess developmental neurotoxicity. Cell Culture

Techniques. Humana, New York, NY, 2019: 169-193.

Related Services:

MagHelix™ Efficacy Testing Using Zebrafish

NMR-based Pharmacometabonomics

MagHelix™ Toxicity Assays Using Zebrafish

In Vitro ADME-Tox Profiling