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Drug Candidate Optimization

Lead Discovery and Optimization

Lead discovery and optimization play a crucial role to determine the quality of clinical candidates.

After this process, a set of compounds can be screened that interact with the target and the

confirmed hits have specific activity against the target. Creative Biostructure performs

comprehensive lead discovery and optimization solutions including library construction, library

screening (in silico, in vitro and in vivo), hit-to-lead optimization and preclinical evaluation, etc.

How Can We Help You Discover and Optimize Leads?

Modern drug discovery involves the identification of screening hits, medicinal chemistry, and

optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability,

and oral bioavailability. Creative Biostructure adopts optimal strategies to reduce the potential of

side effects of candidates or increase the half-life of candidates during drug discovery procedure.

For lead discovery, we mainly generate hits through three approaches: 1) high-throughput

screening (HTS); 2) virtual screening; 3) fragment-based drug discovery (FBDD). Besides, we support

the discovery of leads from existing leads/drugs and natural products.

Why Partner with Creative Biostructure?

The discovery and optimization of lead compounds requires extensive

multidisciplinary cooperation, and our highly responsive team is made up of

interdisciplinary scientists and specialists in chemistry, structural and

computational biology, drug design, biochemistry, molecular biology, and cell

biology. In addition, the advantages of working with us include:

More than ten years of service experience in the field of structural biology

makes us good at structural drug design against targets

The advanced computational drug design platform assisting in early-stage

conceptual design, virtual screening, and modeling studies

Zebrafish screening platform to investigate possible drug-like effects

Extensive experience in drug discovery projects targeting GPCR, kinases,

phosphatases and epigenetic proteins

Customized drug discovery strategies to identify lead compounds and

preclinical drug candidates according to specific demands of customers