Hit Identification in Drug Discovery: Customized Solutions from Creative Biostructure, Slides of Biology

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Compound Library Screening

Hit Identification

Finding active compounds targeting a biological target is the first step

in a drug discovery project, a process known as hit identification, and

it can be challenging. In drug discovery programs, faster progress and

lower attrition rates can be achieved by obtaining high-quality hits.

There are many approaches to achieve this goal, from traditional high-

throughput screening to virtual screening, fragment-based technology

to high content screening. Creative Biostructure offers a range of

customized solutions to help you succeed in the hit identification

process. Our team will design a strategy for the project based on the

nature of the project and the information available and the

approaches we provide can be applied individually or in parallel.

The screening library is a significant tool for lead compound discovery

and selecting the right screening set can greatly increase the speed

and ultimate success of the drug development program. Creative

Biostructure has rich compound library resources, which can be

applied to high-throughput screening (HTS), in silico virtual screening,

fragment-based screening (FBS), and high-content screening (HCS).

Each library can be used for individual screening or combined

screening with other libraries, allowing a tailored approach to project

requirements to maximize the coverage of the chemical space and the

chance of finding hits.

We have assembled some relevant focused/diverse screening libraries

for hit screening. These libraries cover research areas (such as tumor

and epigenetics), signal pathways (such as TGFβ, mTOR, and NF-κB),

and hot protein targets (such as GCPRs, kinases and ion channels).

Regardless of the level of known information about the target, and

whatever screening technique you wish to choose, Creative

Biostructure can design a focused and structurally diverse screening

library to meet your needs and budget.

Related Services:

Lead Optimization and Preclinical Development

Natural Product Identification and Production

Hit to Lead

Excerpt from:

https://drug-discovery.creative-biostructure.com/hit-

identification-p