Lead Discovery and Optimization Solutions by Creative Biostructure, Slides of Biology

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Drug Candidate Optimization

Lead discovery and optimization play a crucial role to determine the quality of clinical candidates. After

this process, a set of compounds can be screened that interact with the target and the confirmed hits

have specific activity against the target. Creative Biostructure performs comprehensive lead discovery

and optimization solutions including library construction, library screening ( in silico , in vitro and in vivo ),

hit-to-lead optimization and preclinical evaluation, etc.

How Can We Help You Discover and Optimize Leads?

Modern drug discovery involves the identification of screening hits, medicinal chemistry, and

optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and

oral bioavailability. Creative Biostructure adopts optimal strategies to reduce the potential of side

effects of candidates or increase the half-life of candidates during drug discovery procedure.

For lead discovery, we mainly generate hits through three approaches: 1) high-throughput screening

(HTS); 2) virtual screening; 3) fragment-based drug discovery (FBDD). Besides, we support the discovery

of leads from existing leads/drugs and natural products.

Why Partner with Creative Biostructure?

The discovery and optimization of lead compounds requires extensive multidisciplinary cooperation,

and our highly responsive team is made up of interdisciplinary scientists and specialists in chemistry,

structural and computational biology, drug design, biochemistry, molecular biology, and cell biology. In

addition, the advantages of working with us include:

More than ten years of service experience in the field of structural biology makes us good at

structural drug design against targets

The advanced computational drug design platform assisting in early-stage conceptual design, virtual

screening, and modeling studies

Zebrafish screening platform to investigate possible drug-like effects

Extensive experience in drug discovery projects targeting GPCR, kinases, phosphatases and

epigenetic proteins

Customized drug discovery strategies to identify lead compounds and preclinical drug candidates

according to specific demands of customers

Welcome to contact us or send an email to [email protected] for project quotations and

more detailed information.

Related Services:

• Target 3D Structure Analysis