High-Content Screening: Comprehensive Drug Discovery Technology by Creative Biostructure, Slides of Biology

Download High-Content Screening: Comprehensive Drug Discovery Technology by Creative Biostructure and more Slides Biology in PDF only on Docsity!

high content

phenotypic screening

In the early stage of drug discovery, traditional target-based high-

throughput screening (HTS) technology has been extensively used in hit

identification due to its high-speed, high-efficiency, and quantitative

characteristics. However, the detection model cannot fully reflect the

biological activity of the selected samples. Cell-based high-content

screening (HCS) technology enables simultaneous screening of

compounds with multiple targets and parameters and realizes a

comprehensive evaluation of the druggability of a compound at the

cellular level.

The HCS equipment of Creative Biostructure includes a high-resolution

automated fluorescence image acquisition system, image analysis and

processing software and data management system. Meanwhile, we are

also equipped with an automated sample loading module and an

environmental control system for long-term automated experimental

analysis.

Our High-content Screening services service can help you:

Clarify the interaction between screened compounds and the drug

target

Understand multiple biological changes of cells and obtain

spatiotemporal information about cellular events

Study the effects of screened compounds on related metabolic

pathways

Predict the toxicity of compounds by observing cell morphology

Realize high-throughput screening of candidates and quickly find the

effective components of drugs

Advantages of our High-content Screening services:

We have several compound libraries, which can be widely used in HCS,

and can also customize libraries according to project requirements.

Advanced and automated equipment and analysis software meet the

requirements of high-throughput screening.

Parallel data collection and analysis of multiple samples with 96- or

384-well plates can be performed.

Rich experience in high-throughput screening and image analysis

enables us to select appropriate cell types and parameters before

launching the HCS project.

Reference

Jo A.; et al. A high-content screening platform with fluorescent

chemical probes for the discovery of first-in-class

therapeutics. Chemical Communications. 2016, 52(47): 7433-7445.

Excerpt from:

https://drug-discovery.creative-biostructure.com/high-content-

screening-p