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Lecture notes for Metabolism and instructions
Typology: Lecture notes
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Catecholamines
used to treat an underactive thyroid gland (hypothyroidism). The thyroid gland makes thyroid hormones which help to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone thyroxine. Levothyroxine is only available on prescription
used to treat hyperthyroidism and Graves' disease , a condition where the thyroid gland produces too much thyroid hormone which speeds up metabolism causing other issues. It is also used before thyroid surgery or radioactive iodine treatment in patients who have already been treated with other medicines (e.g., methimazole) that did not work well; It works by stopping the thyroid gland from making thyroid hormone Monitor LFT (liver func. test) 30 min in AM prior to eating for absorption Caution : liver fail; may need liver transplant *DO NOT give to children Can have adjunct therapy – Beta blockers Iodine solution – inhibit release of T4 and T3 can be given prior to surg Cause staining of teeth drink out of straw Radioactive Iodine : out patient, not use in preg or breast feeding Avoid preg for 6 month after treatment Do NOT lay child on chest because iodine comes out thru sweat ** Do NOT know how much of the thyroid it will destroy ** Relief of symptoms aren’t instant & can take about 6-8 wks
Surgery – Don’t respond to other treatments, Goiter too big and causes blockage Total Thyroidectomy – Complete removal; will need Levothyroxine Sub Thyroidectomy STOP ASPIRIN; bleeding and cause slow clotting Post op: hemorrhaging, Resp. distress, Twitching, Need tracheostomy tray at BS for emergency tray
used to treat overactive thyroid (hyperthyroidism). It works by stopping the thyroid gland from making too much thyroid hormone DO NOT give to pregnant women
Osteoporosis is characterized by reduced bone mass, deterioration of bone matrix, and diminished bone architectural strength. Osteopenia
loss of height gradual development of thoracic back pain that is relieved by lying down most patients are asymptomatic even in the presence of vertebral compression fracture can experience pain from minimal trauma fracture (also called stress fracture) o acute vertebral compression fracture o hip fracture, or other fractures o Osteoporosis-induced kyphosis (i.e., exaggerated rounding of the upper back) can reduce lung volume, impair rib mobility, and impair respiratory function o Labs/Diagnostics Vitamin D and calcium levels 24-hour calcium/creatinine levels to look for malabsorption diseases Thyroid stimulating hormone to evaluate thyroid function Blood and urine biochemical markers of bone turnover (e.g., serum bone- specific alkaline phosphatase, urinary N-telopeptide) will be elevated and can predict rate of bone loss and measure therapy response Testosterone, luteinizing hormone, and follicle stimulating hormone to evaluate for hypogonadism BMD T-score ≤-2.5 on DEXA of the lumbar spine and hip DEXA also measures therapeutic response o Low levels of x-ray to measure how dense your bones are X-ray to evaluate for suspected fracture Treatments Relieve Pain and Other Symptoms and Reduce Risk for Complications
resorption (see the series of Quick Lessons on individual drugs) Teriparatide (recombinant human parathyroid hormone)to promote bone formation Denosumab (RANK-Ligand inhibitor)to inhibit bone resorption by inhibiting osteoclast formation, function, and survival Calcitonin to reduce bone resorption by reducing the activity and number of osteoclasts; it is US FDA-approved for treatment of osteoporosis in women ≥ 5 years postmenopause who are unable to use other therapies. It is less effective than bisphosphonates in reducing nonvertebral fracture risk and increasing BMD Provide Emotional Support and Education