Lecture notes for Metabolism, Lecture notes of Nursing

Lecture notes for Metabolism and instructions

Typology: Lecture notes

2023/2024

Uploaded on 02/26/2026

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Metabolism
Catecholamines
-Dopamine, Norepinephrine, Epinephrine
-A type of neurohormone (a chemical that is made by nerve cells and
used to send signals to other cells)
-Catecholamines are!important in stress responses
oHigh levels cause high blood pressure which can lead to
headaches, sweating, pounding of the heart, pain in the chest,
and anxiety
Levothyroxine
used to treat an underactive thyroid gland (hypothyroidism). The thyroid
gland makes thyroid hormones which help to control energy levels and
growth. Levothyroxine is taken to!replace the missing thyroid hormone
thyroxine. Levothyroxine is only available on prescription
Propylthiouracil
used!to treat hyperthyroidism and Graves' disease , a condition where
the thyroid gland produces too much thyroid hormone which speeds up
metabolism causing other issues. It is also used before thyroid surgery or
radioactive iodine treatment in patients who have already been treated with
other medicines (e.g., methimazole) that did not work well; It works by
stopping the thyroid gland from making thyroid hormone
Monitor LFT (liver func. test)
30 min in AM prior to eating for absorption
Caution : liver fail; may need liver transplant
DO NOT give to children
Can have adjunct therapy – Beta blockers
Iodine solution – inhibit release of T4 and T3 can be given prior to
surg
Cause staining of teeth *drink out of straw
Radioactive Iodine : out patient, not use in preg or breast feeding
Avoid preg for 6 month after treatment
Do NOT lay child on chest because iodine comes out thru
sweat
** Do NOT know how much of the thyroid it will destroy
** Relief of symptoms aren’t instant & can take about 6-8 wks
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Metabolism

Catecholamines

  • Dopamine, Norepinephrine, Epinephrine
  • A type of neurohormone (a chemical that is made by nerve cells and used to send signals to other cells)
  • Catecholamines are important in stress responses o High levels cause high blood pressure which can lead to headaches, sweating, pounding of the heart, pain in the chest, and anxiety

Levothyroxine

used to treat an underactive thyroid gland (hypothyroidism). The thyroid gland makes thyroid hormones which help to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone thyroxine. Levothyroxine is only available on prescription

Propylthiouracil

used to treat hyperthyroidism and Graves' disease , a condition where the thyroid gland produces too much thyroid hormone which speeds up metabolism causing other issues. It is also used before thyroid surgery or radioactive iodine treatment in patients who have already been treated with other medicines (e.g., methimazole) that did not work well; It works by stopping the thyroid gland from making thyroid hormone Monitor LFT (liver func. test) 30 min in AM prior to eating for absorption Caution : liver fail; may need liver transplant *DO NOT give to children Can have adjunct therapy – Beta blockers Iodine solution – inhibit release of T4 and T3 can be given prior to surg Cause staining of teeth drink out of straw Radioactive Iodine : out patient, not use in preg or breast feeding Avoid preg for 6 month after treatment Do NOT lay child on chest because iodine comes out thru sweat ** Do NOT know how much of the thyroid it will destroy ** Relief of symptoms aren’t instant & can take about 6-8 wks

Surgery – Don’t respond to other treatments, Goiter too big and causes blockage Total Thyroidectomy – Complete removal; will need Levothyroxine Sub Thyroidectomy STOP ASPIRIN; bleeding and cause slow clotting Post op: hemorrhaging, Resp. distress, Twitching, Need tracheostomy tray at BS for emergency tray

Methimazole- Tapazole

used to treat overactive thyroid (hyperthyroidism). It works by stopping the thyroid gland from making too much thyroid hormone DO NOT give to pregnant women

Osteoporosis

Osteoporosis is characterized by reduced bone mass, deterioration of bone matrix, and diminished bone architectural strength. Osteopenia

  • low bone mineral density [BMD])—the precursor to osteoporosis Peak adult bone mass
  • achieved between the ages of 18 and 25 years in both women and men and
  • affected by genetic factors, nutrition, physical activity, medications, endocrine status, and general health
  • Men have heavier bones than women so they manifest osteoporosis at advance age Interventions
    1. increased calcium and vitamin D intake
    2. participation in regular weight-bearing exercise

S/S

 loss of height  gradual development of thoracic back pain that is relieved by lying down  most patients are asymptomatic even in the presence of vertebral compression fracture  can experience pain from minimal trauma fracture (also called stress fracture) o acute vertebral compression fracture o hip fracture, or other fractures o Osteoporosis-induced kyphosis (i.e., exaggerated rounding of the upper back) can reduce lung volume, impair rib mobility, and impair respiratory function o Labs/Diagnostics  Vitamin D and calcium levels  24-hour calcium/creatinine levels to look for malabsorption diseases  Thyroid stimulating hormone to evaluate thyroid function  Blood and urine biochemical markers of bone turnover (e.g., serum bone- specific alkaline phosphatase, urinary N-telopeptide) will be elevated and can predict rate of bone loss and measure therapy response Testosterone, luteinizing hormone, and follicle stimulating hormone to evaluate for hypogonadism BMD T-score ≤-2.5 on DEXA of the lumbar spine and hip  DEXA also measures therapeutic response o Low levels of x-ray to measure how dense your bones are  X-ray to evaluate for suspected fracture Treatments  Relieve Pain and Other Symptoms and Reduce Risk for Complications

  • Assess fall risk and maintain patient safety (i.e., airway, circulation, injury prevention)
  • Assess for pain and evaluate level of physical disability; encourage side-lying or supine positions with knees flexed on a firm mattress; promote good posture and body mechanics, and provide local heat and gentle back massage to promote  muscle relaxation and reduce pain as ordered  administer prescribed analgesics
  • Monitor bowel function; minimize constipation with a high- fiber diet, increased fluids, and prescribed stool softeners
  • Follow pre- and postoperative protocols if patient becomes a surgical candidate for fracture repair (e.g., hip pinning, vertebroplasty); reinforce education and verify completion of facility informed consent documents  Administer prescribed medications, which can include the following:  Bisphosphonates (e.g., alendronate, risedronate, zoledronate) or the estrogen agonist/antagonist raloxifene to inhibit bone thinning

 resorption (see the series of Quick Lessons on individual drugs)  Teriparatide (recombinant human parathyroid hormone)to promote bone formation  Denosumab (RANK-Ligand inhibitor)to inhibit bone resorption by inhibiting osteoclast formation, function, and survival  Calcitonin to reduce bone resorption by reducing the activity and number of osteoclasts; it is US FDA-approved for treatment of osteoporosis in women ≥ 5 years postmenopause who are unable to use other therapies. It is less effective than bisphosphonates in reducing nonvertebral fracture risk and increasing BMD  Provide Emotional Support and Education

  • Educate patient about prescribed osteoporosis drugs and common adverse reactions, including  dysphagia, esophagitis, esophageal and gastric ulcers with bisphosphonates  rhinitis and back pain with raloxifene  leg cramps and dizziness with teriparatide
  • Discuss lifestyle modifications: Daily calcium (1,000–1, mg) and vitamin D (800–1,000 IU) intake (preferably dietary,  supplements if necessary); reduced caffeine and alcohol intake; smoking cessation; and regular exercise (e.g., tai chi, yoga)  to improve balance and muscle tone
  • Teach fracture-prevention measures (e.g., good body mechanics; hip protectors and/or back braces;no sudden bending, Anticonvulsant
  • DILANTIN is a prescription medicine used to treat certain types of seizures called tonic-clonic (grand mal) and psychomotor (temporal lobe) seizures and to prevent and treat seizures that happen during or after brain surgery