NSG //533 //Opioid //Quiz //With //Correct //Answers //
Endogenous //opioid //peptides
Small //molecules //that //are //naturally //produced //in //the //CNS //and //in //various //glands
//throughout //the //body, //such //as //the //pituitary //and //adrenal //glands. //Consists //of //endorphins,
//enkephalins, //dynorphins, //and //nociceptins.
Mechanism //of //action //for //opioids
Stimulating //opioid //u-receptors //in //the //CNS. //Pure //agonists //(morphine) //bind //to //u-receptors
//to //produce //analgesia //that //increases //with //dose //without //a //ceiling //effect. //Partial //agonists
//at //the //u-receptor //(Buprenorphine, //tramadol) //cause //less //conformational //change //and
//receptor //activation //than //full //agonists.
Indications //for //initiating //opioid //therapy
Used //when //benefits //outweigh //risks //associated //with //opioids //such //as //abuse. //Used //for
//acute //pain //(including //post-surgical) //from //under //a //month, //and //chronic //pain.
Tolerance
the //diminishing //effect //with //regular //use //of //the //same //dose //of //a //drug, //requiring //the //user
//to //take //larger //and //larger //doses //before //experiencing //the //drug's //effect
Dependence
the //condition //that //results //when //the //brain //develops //a //chemical //need //for //a //drug //and
//cannot //function //normally //without //it
