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Quick Notes Clinical Pathology
Typology: Exams
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Sensitivity of a Test -
Gray Fluoride Tube - Has sodium fluoride Stops metabolism of glucose Used to measure glucose or lactate Decreased RBC or PCV - Indicated Anemia MCV or Mean Cell Volume - Used to evaluate anemia Microcytic - 1 - Iron deficiency 2 - Portosystemic shunt 3 - Akitas & Shiba inus Macrocytic - 1 - Regenerative anemia 2 - agglutination - IMHA - artifact 3 - โ vitamin b12/folic acid - not really a cause in domestic animals 4 - FELV - a myeloproliferative disease/erythroid dysplasia due to virsus 5 - Poodles - hereditary stomatocytosis - effected dogs are nor anemic 6 - Drugs - phenobarb, phenytoin, primodone MCHC or Mean Cell Hemoglobin Concentration - Used to classify anemias Causes of Increased MCHC - 1 - Hemolysis 2 - Lipemia 3 - Large #'s of heinz bodies in cats 4 - Icterus 5 - Oxyglobin 6 - Extreme leukocytosis Causes of Decreased MCHC - 1 - Severe iron deficiency 2 - Regenerative anemia Reticulocyte Count -
Purpose of Blood Films - 1 - Determination of the [ ] of individual leukocytes 2 - Assessment of cell morphology Technique Used To Make Blood Films - Push technique Artifacts Associated With Slow Drying of Blood Films - 1 - Crenation 2 - Refractile artifacts - can look like hemo-parasites 3 Areas of A Blood Film - 1 - Body 2 - Counting Area 3 - Feathered Edge Blood Films - Body -
Neutrophil - Metamyelocyte -
*If seen in blood it is an artifact of aged blood prepared 12 hours after collection Neutrophils Abnormalities - Inherited Abnormalities - 1 - Pelger-Huet anomaly 2 - Briman cat neutrophil granulation anomaly 3 - Lysosomal storage disorder 4 - Chediak Higashi syndrome 5 - Cyclic hematopoiesis in gray collies Pelger-Huet Anomaly -
โ Neutrophils & โ Lymphocytes -
Heinz Body Anemia -