Overview of Creative Biostructure's MagHelix™ SPR Services in Drug Discovery, Slides of Biology

Download Overview of Creative Biostructure's MagHelix™ SPR Services in Drug Discovery and more Slides Biology in PDF only on Docsity!

spr fragment screening

Optical biosensors have been utilized widely in many links and areas of drug discovery,

such as target identification, ligand screening, lead compound selection, early ADME as

well as manufacturing quality control. Among them, surface plasmon resonance (SPR)

technology is a rapidly developing approach for determining binding events, which can

characterize target protein-ligand interactions in real time. Creative Biostructure has

extensive expertise and experience in SPR technology, and we can exploit this

technology to provide sensitive, rapid, and reliable assays to help you measure real-

time binding and kinetic information of ligands against specific targets. Our MagHelix™

SPR is a customizable solution that optimizes procedure for specific drug discovery

projects, from experimental design to downstream applications.

Briefly, the advantages of SPR include: 1) It is highly sensitive and suitable for detecting weak target-ligand

interactions mediated by fragments; 2) Without labels and the detection of false positives caused by fluorescence

quenching can be excluded; 3) Relatively small quantities of samples can be used for measuring real-time

quantitative kinetics and binding affinity; 4) The medium-throughput mode makes it available as a tool for

screening ligands. However, information about the binding site or pharmacophore of a ligand cannot be obtained.

Advantages of our MagHelix™ Surface Plasmon Resonance (SPR) services:

Based on powerful Biacore and Fortebio systems, we have provided customers with many high-quality solutions

for monitoring interactions between various proteins, DNA/RNA as well as small/complex molecules.

We have many years of experience in monitoring biomolecular interactions such as protein-small molecule,

protein-peptide, protein-protein, antigen-antibody, and so on.

We can combine SPR technology with fragment-based screening approach for medium-throughput screening of

chemical libraries.

The next-generation SPR instruments enable us to analyze the ligand binding to membrane proteins in a more

native environment.

Using SPR technology to screen and characterize antibodies to understand their affinity and kinetic characteristics.

At Creative Biostructure , we can offer corresponding compound libraries or fragment libraries for ligand screening,

and we also provide other biophysical solutions to characterize the binding kinetics of hit compounds or fragments

. Want to know more? Please do not hesitate to contact us for more information.

Thank you!

Excerpt from:

https://drug-discovery.creative-biostructure.com/maghelix-

surface-plasmon-resonance-spr-p