Comunicació celular, Apuntes de Psicología Fisiológica

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Mechanisms of

cellular

communication

Via, M. & Segarra, M.D.

Departament de Psiquiatria i Psicobiologia Clínica Barcelona February 11-20, 2014

Bear, M.F., Connors, B.W. y Paradiso, M.A. (2008). Neurociencia. La exploración del cerebro. Barcelona: Wolters Kluwer Health España. Redolar, D. (2010). Fundamentos de psicobiología. Barcelona: UOC. Outline -Neurotransmitters and neuromodulators concept and criteria for characterization types functional implications -Hormones concept hypothalamic-pituitary anterior and posterior lobes of the pituitary functional implications

Neurotransmitters substances that induce the opening of ion channels when interacting with a receptor Neuromodulators substances that regulate synaptic transmission when interacting with a receptor Neurotransmitters and neuromodulators

Ionotropic Receptor Metabotropic Receptors Neurotransmitters and neuromodulators

Short and long-term effects of NMs Neurotransmitters and neuromodulators

Neurotransmitters and neuromodulators Redolar, D. (2010). Fundamentos de psicobiología. Barcelona: UOC.

Pharmacology of synapsis: Interacting with NT receptors Neurotransmitters and neuromodulators

Redolar, D. (2010). Fundamentos de psicobiología. Barcelona: UOC.

Acetylcholine (ACh)

Cortical arousal

REM sleep Acetylcholine (ACh)

Acetylcholine (ACh) ACh ACh ACh ACh

Monoamines: catecholamines Dopaminergic neurons Noradrenergic neurons Adrenergic neurons

Monoamines: dopamine (DA)

Motor function (fine)

(Parkinson)

Nigrostriatal pathway

Mesocortical pathway -- Short-term memory, planning

Mesolimbic pathway

Emotions, rewards

(addictions) (Schizophrenia) Monoamines: dopamine (DA) Ventral tegmental area