Ibuprofen Summary
Ibuprofenis an NSAID and non-selective COX inhibitor used to
treat mild-moderate pain, fever, and inflammation.
Brand Names
Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM,
Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's
Ibuprofen, Combogesic, Diphen, Duexis, Ibu, Ibutab, Junior Strength
Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal,
Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-
profen Congestion Relief and Pain
Generic Name
Ibuprofen
DrugBank Accession Number
DB01050
Background
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from
propionic acid and it is considered the first of the propionics.The formula
of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial
development was in 1960 while researching for a safer alternative for
aspirin. Ibuprofen was finally patented in 1961 and this drug was first
launched against rheumatoid arthritis in the UK in 1969 and USA in
1974. It was the first available over-the-counter NSAID.
On the available products, ibuprofen is administered as a racemic
mixture. Once administered, the R-enantiomer undergoes extensive
interconversion to the S-enantiomerin vivoby the activity of the alpha-
methylacyl-CoA racemase. In particular, it is generally proposed that the
S-enantiomer is capable of eliciting stronger pharmacological activity
than the R-enantiomer.
Type
Small Molecule
Groups
Approved
Structure
