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Lorenzo Oil Projects, Apuntes de Inglés Técnico

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Tipo: Apuntes

2018/2019

Subido el 11/04/2019

yarrieta13
yarrieta13 🇵🇦

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Film: Lorenzo’s Oil – Part One
Directions: Answer the following questions based on the information provided in the film,
Lorenzo’s Oil.
1. Lorenzo begins to experience problems at school and at home. What symptoms of the
disease first
appeared?
_________________________________________________________________________
_________________________________________________________________________
2. What medical tests were done to assess Lorenzo’s condition?
_________________________________________________________________________
_________________________________________________________________________
3. When Lorenzo is diagnosed with Adrenoleukodystrophy, the doctor explains the prognosis
for this disorder. What does he tell Mr. and Mrs. Odone?
________________________________________________________________________
________________________________________________________________________
5. The inheritance pattern for this disease is referred to as _______________
___ __ _________________________________________________________
6. Lorenzo inherited this disease from which parent?
___________________ _______________________________________________
___________________
7. The biochemical basis of this disease is related to the metabolism of what molecules?
_________________________________________________________________________
_________________________________________________________________________
Biology 30S Name
Science Movie Worksheets – http://www.NewYorkScienceTeacher.com/movies
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Film: Lorenzo’s Oil – Part One

Directions: Answer the following questions based on the information provided in the film, Lorenzo’s Oil.

  1. Lorenzo begins to experience problems at school and at home. What symptoms of the disease first appeared?


  1. What medical tests were done to assess Lorenzo’s condition?


  1. When Lorenzo is diagnosed with Adrenoleukodystrophy, the doctor explains the prognosis for this disorder. What does he tell Mr. and Mrs. Odone?


  1. The inheritance pattern for this disease is referred to as _______________

  1. Lorenzo inherited this disease from which parent?


  1. The biochemical basis of this disease is related to the metabolism of what molecules?


  1. What is myelin?


  1. How is the buildup of molecules affecting the myelin sheath of Lorenzo’s neurons?


  1. What two trial studies did Lorenzo’s parents try to help their son fight the disease?


  1. What changes are apparent in the lives of the Odone’s that are related to Lorenzo’s illness?


  1. What decision did Lorenzo’s parents make about the way they would fight the disease to save their son?


  1. How was Lorenzo’s disease progressing?


Film: Lorenzo’s Oil – Part Two

Directions: Answer the following questions based on the information provided in the film, Lorenzo’s Oil.

  1. What is the attitude of the people in the foundation towards research and new treatments?

  1. Where did Lorenzo’s father get this oil?


  1. How did Lorenzo consume the oil?


  1. How is Lorenzo’s response to the oil measured? This oil is only partially effective; explain why.


  1. What does the paper clip model demonstrate to Augusto? What is his dream?


  1. When Augusto explains the dream to the doctor, the paper clip model is shown to have this property of an enzyme reaction?

_________________________________________________________________________

Film: Lorenzo’s Oil – Part Three

Directions: Answer the following questions based on the information provided in the film, Lorenzo’s Oil.

  1. What is the name of the second oil?

_________________________________________________________________________

  1. What plant is this oil is extracted from?


  1. What is the medical basis of using this oil?


  1. Who is Lorenzo’s rat?


  1. Why can the therapy of erucic acid be tested on Michaela’s sister or Michaela?

_________________________________________________________________________

  1. Why are the doctors and family concerned about toxicity?


  1. At this point, what is Lorenzo’s condition?


  1. How is Lorenzo breathing?


  1. After the administration of the oil, how does Lorenzo’s condition begin to change?


  1. When the Odone’s present their findings how do the parents in the foundation respond?

For answers that require more than one word, your answer must

be in complete sentences.

  1. What does the term VLCSFA stand for?
  2. Focus on a single link in the hydrocarbon tail of a VLCSFA. What are the elements that make up that link and how many atoms of each element are contained in each link?
  3. What does the term VLCUFA stand for and how is it different than a VLCSFA? Draw a diagram showing the different linkages.
  4. What two parts of the body are most damaged by ALD?
  5. What are the two sources of VLCSFAs in the body?
  6. Name and describe the part of the cell in which VLCSFAs are synthesized by the body.
  7. What are peroxisomes and what is their role in maintaining safe levels of VLCSFAs in normal people?
  8. What do normal people have that ALD patients lack?
    1. Describe the model that Augusto Odone developed to show the problem of reducing VLCSFAs in Lorenzo's body.
  9. What was the contribution of the article by the Polish chemists and where did it leave the Odones?
  10. Explain how Lorenzo's Oil works to prevent the buildup of VLCSFAs in the body.
  11. In the movie, the Odones were confronted with a number of questions that they had to answer. An early question was why Lorenzo's VLCSFA levels went up even when the VLCSFAs were

eliminated from his diet. Hopefully, by looking at the sink model you know the answer. (It is that VLCSFAs were still being made by biosynthesis.) Another question the Odones had to answer was why biosynthesis of saturated fats was reduced when Lorenzo was given oleic acid, an unsaturated fat. Why did that occur?

  1. Does Lorenzo's Oil correct the damage done by VLCSFA's?
  2. When do symptoms of ALD appear and how many boys with the defective ALD gene will actually get the disease and show symptoms during that period?
  3. Name five symptoms of ALD.
    1. What is the prognosis for patients with untreated ALD?
    2. What is the earliest point at which ALD can be diagnosed with modern medical techniques?
    3. Name two current treatments for ALD.
    4. Are excessive levels of VLCSFAs part of the cause of the deterioration of the myelin sheath in ALD sufferers or is it a mere byproduct of that process? How do we know this?
    5. What is adrenomyelonueropathy (AMN), how does it relate to ALD, and who gets it?
  4. The Odones were very lucky in their effort to find a way to arrest the progress of ALD in their son. One of the reasons that the scientists were reluctant to immediately publish the remarkable drop in the level of VLCSFAs in Lorenzo's blood was that they had no idea of what Lorenzo's Oil would do to the human body. Focus on the different possible effects of competitive inhibition and describe a possible scenario for damage that could have been caused by the ingestion of Lorenzo's Oil.