Degraded or
malfunctioning
osteocytes may lead to
various pathological
conditions, such as
hypophosphatemic
rickets, sclerosteosis,
and necrotic bone.
Osteocytes, source of
sclerostin, are the main
integrators of
mechanical and chemical
signals that lead to
significant changes
within the human body.
Microscopy
Light: The
visualization of
sclerostin
confirms the
presence of
osteocytes in
the bone pieces.
Usually use trabecular
bone samples from the
anterior iliac crest,
as this sample can be
collected from healthy
patients as surgical
waste material from
procedures
Osteocyte
resides within
the lacunae
located between
the lamellae of
the matrix.
Each lacuna
consists of one
osteocyte.
Specially built with
innate proteins that
help them to survive
in hypoxic
conditions
osteocytes maintain
biomineralization.
OstOstOsteocyteseocyteseocytes
Not only do
osteocytes contribute
to bone mass via
controlling
osteoblast and
osteoclast activity,
but these cells act
as main players in
phosphate metabolism.
A mature
osteocyte holds
a single
nucleus, which
has a membrane
and one or two
nucleoli.
Osteonecrosis refers to
the classic pattern of
cell death and complex
osteogenesis and bone
resorption processes.
Elaborado por
G E RA L D IN E LO R E NA R U IZ R OD R I GU E Z .
