Conceitos de Fluidos Corporais e Leis de Starling, Notas de estudo de Física

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Anatomy and Physiology

Bi 145b

Jim Pierce, MD Lecture One Second Term, 2009-

Course Policies

• (^) Lecture Hours
  • (^) Monday 730-
  • (^) Wednesday 730-
• (^) Location: Kerkhoff 119

Course Policies

• (^) TAs
  • (^) Trisha Sando
  • (^) Sam Huang
  • (^) Elizabeth Mak
  • (^) Nick Goeden
  • (^) Monica Williams
• (^) Office Hours

Course Goals

• (^) Embryology
• (^) Anatomy
• (^) Microanatomy
• (^) Cellular Physiology
• (^) Organ Physiology
• (^) Integrative Physiology

Questions?

Body Fluids

• (^) To understand Renal Physiology,

we must first talk about body water

and electrolytes

• (^) Approximately 60% of the body is water.

Body Fluids

• (^) For a 70 kg man whose body read the

book:

• (^) Total Body Water = 42 Liters
• (^) Intracellular Water = 28 Liters
• (^) Extracellular Water = 14 Liters

Body Fluids

• (^) Intracellular Fluid is easy:

It’s all inside the cells

• (^) Extracellular Fluid exists in two locations:
  • (^) Intravascular (1/4 in blood vessels)
  • (^) Interstitial (3/4 in tissues)

Body Fluids

• (^) What are the barriers between these

three body spaces?

• (^) Intracellular
• (^) Interstitial
• (^) Intravascular

Body Fluids

• (^) Between Intracellular and Interstitial

is the CELL MEMBRANE

• (^) Between Interstitial and Intravascular

is the CAPILLARY MEMBRANE

Body Fluids

• (^) Why are these barriers important?Why are these barriers important?
• (^) Only blood (intravascular) goesOnly blood (intravascular) goes to the kidney for processing. to the kidney for processing.
• (^) The diffusion limitations of theseThe diffusion limitations of these barriers determine how accessible barriers determine how accessible things are to the kidney things are to the kidney

Body Fluids

Intracellular Interstitial Intra vascular

Body Fluids

• (^) Proteins and their bound water
• (^) Small covalent compounds
  • (^) Some bound to protein (lipophilic)
  • Some with bound water
• (^) Lipoproteins
• (^) Salts and their bound water
  • (^) Sodium, Chlorine
  • (^) Bicarbonate

Interstitial Space

• (^) The source of the Interstitial ECM is regional.The source of the Interstitial ECM is regional.
• (^) Proteins (Fibers and Ground substance) often comeProteins (Fibers and Ground substance) often come from the connective tissue cells from the connective tissue cells
• (^) Salt, Water, and small molecules areSalt, Water, and small molecules are “Filtered” by the capillary membrane “Filtered” by the capillary membrane
• (^) Waste Products are removed by theWaste Products are removed by the Blood and Lymphatics Blood and Lymphatics
• (^) Hormones are produced and consumedHormones are produced and consumed everywhere. everywhere.