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mmartTaz. í 0 í—ÃJGÇÃÃE&EVy SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photonies Partner 00 Fundamentals of Raman spectroscopy and Instrumentation Laser Focus World 9/22/2011 bl) ] e *e e 0 V'20/2011 Travis Thompson — Bs Tek Inc. 1 ver prtek.com BMV INC. SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q e O) Your Photomes Partner 00 History of Raman Spectroscopy 1928: CV. Raman and Krishnan discover Raman effect 1930s: Raman is recognized as a principal means of non-destructive chemical analysis 1960s: Revived interest in Raman develops due to acdvent of lasers 1986: First FT-Raman instrumentation is developed 1990s: Dispersive Raman instrumentation is developed, including compact NIR lasers, multi-channel detectors, fiber-optic probes. ud - Portable integrated dispersive Raman systems are developed hd “o Applications of Raman spectroscopy in various fields starts to id “e: become a reality 7/28/2011 Travis Thompson — Bewv Tek Inc. 2 ver prtek.com mmartTaz. í 0 í—ÃJGÇÃÃE&EVy SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photonies Partner 00 Raman Scattering Classical Wave Interpretation CH;-CH;-0H I Arlo ad Quantum Particle Interpretation 0) o o o) » CH-CH-0OH T'28/2011 Travis Thompson — BS TEk Inc. Ei ver prtek.com BMV IH qr SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photomies Partner 00 Classical Derivation of the Raman Effect Xj K X3 1; 5 dx d Hooke's MM o + "a = —K(x + Ka ] —— m+m| dé dt Law: F=-Kx Reduced Mao, d q Assicemen 5 =-Kq dt q | E [1 => = qn coslZmm, t Ma S— |— ” e q= qo cos(2nv at) 1 ln O] e 0 V1202011 Travis Thompson — Bs Tek Inc. 5 ver prtek.com BM TE SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photomies Partner 00 Quantum Energy Scheme for Photon Scattering o E Mmade pç Prcanerea = ORÃ, E) hvo |hvothva E] E — Smoj M aii, MM fea M, aárini DM nal Õ vo |hvo Ava [voy 2 gh F E =p oil, * Una Tp | Egthva | ! ” En P, Scattered X 2 Rayleigh Stokes Anti-Stokes Seattering Seattering Seattering ]) (elastic) Y The E ff; Re a Ver [) Rabin he Raman effect comprises a very NS o (inelastie) small fraction, about 1 in 107, of the o amncident photons. e e 0 26/2011 Travis Thompson — Bs Tek Inc. 7 ver prtek.com Õ Your Photomies Partner 00 Excitation Wavelengths DPS5xá : N 532mm Hesg/Necu 263-266 an Ar DP55x2 HeNe Semiconductor N Laser 224/248 365-405 488 532nm 633nm 785nm . N a 633nm N Laser 785nm,| + Laser | o | PN 400 500 600 700 800 900 o ] Fluorescence region e . 0 26/2011 Travis Thompson — Bs Tek Inc. B ver prtek.com BMWV INC. SPECTROMETERS | LASERS | Your Photomies Partner Sampling * Fiber optics provide very flexible sampling for Raman spectrometers * Fiber optic probes can also be easily adapted to a variety of different sampling chambers — Liquidflom cells — Gas flow cells — Optical microscopes * High OD provides low Raman cut- T'28/2011 Travis Thompson — BS TEk Inc. ver prtek.com 10 BWV INC. SPECTROMETERS | LASERS | TOTAL SOLUTIONS 0, Q º O) Your Photomes Partner 00 Raman Spectral Information (CH;hC=0 E=0 |— CHs * A Raman spectrum is a ad molecular fingerprint' — Alows for development of spectral O CH; clatabases CHCHOR * Raman provides structural s=0 information | (CH,,5=0 J — Bandassignmenitables readily AA available CH;CH:OsCCH; 2 O * Changes in frequency shift and o peak bandwidth also provide 1] valuable information | ArH to 500 1000 1500 2000 2500 3000 O] ad 0 Wavenumbers 7/28/2011 Travis Thompson — Bau Tek Inc. “ ver prtek.com BM TE SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photonies Partner O) O) Pharmaceutical Industry * Raw Material Identification and Verification Analysis of Tablets, Liquids, and Gel Caps * Process Analytical Technology (PAT) — Sine, At-line Monitoring and Control: Real-Time Monitoring of Drying, Coating, and ending * Identification and Analysis of API, Additives, and Excipients * Drug Identification Control: Purity and Quality * Counterfeit Drug Analysis Boo4 A ad Tagrito! aà 0007 Cosbamazaçõo (Geredo Teqgretol) y | | É avo! ] É ooo! hu a] | 20004 lj MR ul, | 10004 Aa] am JM, amo 600 Boo 1090 1200 1400 tE0O 1800 Raman Shit fem ') T'28/2011 Travis Thompson — BS TEk Inc. 13 ver prtek.com mmartTaz. í 0 í—ÃJGÇÃÃE&EVy SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q 1) Your Photonies Partner 00 Food & Agriculture Industry Ephedrine * Measuring Chain Length and Extent of Saturation of Fatty Acids in Edible Oils * Meat Product Quality Analysis * SERS Analysis of Food Contaminants Including Bacteria, Antibiotics, Dyes, etc. - Analysis of Components in Grain Kernels * Raw Material Identification/Verification for the Food and Beverage Industries Relativo Intensity 250 500 750 4000 150 1500 1750 2M0 Rama Sbitgm 4 T'28/2011 Travis Thompson — BS TEk Inc. 1d ver prtek.com INC. SPECTROMETE mmartTaz. í 0 í—ÃJGÇÃÃE&EVy BAN Your Photomes Partner Carbon * Diamond * Graphite * Carbon Nanotubes — tube diameter, physical properties * Graphene - thickness AS | LASERS | ma 0 O O o RE Rr ER RE EUR CECESECECECETES Base Te fera 1j RBM — Radial Breathing Modes D Band — Disorder Band Amorphous Character G Band - Tangential Mode, Crystalline Character +'20/2011 Travis Thompson — BEM Tek Inc. 16 ver prtek.com INC. SPECTROMETERS | ASERS | TOTAL SOLUTIONS 0, Q º O) Your Photomes Partner Non-invasive Gemstone Identification and Examination Gemology * Identify Unknown Gemstones by Unique Raman 'Fingerprint * Identification ofPolymorph or Subspecies of E) lá | = | Gemstone E | na Mo do * Analysis ofGemstone Origin through Raman | má Di Microscopy Analysis of Inclusions lee E Ee ES» Anti-counterfeiting-i.e. Distinguish Diamond Eaman shift dom) from Zitcon & e e 0 7/28/2011 Travis Thompson — BEM Tek Ihc. 17 ver prtek.com BMV INC. SPECTROMETERS | LASERS | TOTAL SOLUTIONS 1) Q e O) Your Photonies Partner 00 Bioscience and Medical Diagnosis + Suble Changes Within Biomolecules, je. Drug Interactions, Tissue Healing, Cosmetics, Disease Diagnosis *— Intercellular SERS Localization an dInteraction * Identification of Drug Binding to Cells for Drug-DNA and Cellular Interaction Analysis * Investigation of Microorganisms in Single Cells, YeastCell Classifications, andSingle Bacterum *— Oxygenation Measurements of Blood and Tissue soooo . . . . Human ântibody Detection *— MolecularLevel Cancer Detection (Cervical, Lung, etc.) soco *— Immunoassays Using SERS and Raman Readers 40000 2500 nam. E 4250 ngimL É 20000 “20000 10000 i] 175 65 1175 1675 275 2675 3175 Raman Shift [cm-1) T'28/2011 Travis Thompson — BS TEk Inc. 19 ver prtek.com BMV IH qr SPECTROMETERS | LASERS | TOTAL SOLUTIONS 0 Õ º 1) Your Photonies Partner 00 Handheld Raman Spectroscopy Fastest Growing Segment of Raman Spectroscopy with Countless Applications! Ideal Solution For: * Incoming Material Identification and Verification * At-line Sampling and Final Inspection * Counterfait Drug Detection FZ BZRAM For additional information on any of the products shown in this presentation please visit www.bwtek.com Be e-mail travist(dbwtek.com or call 302-368-7824 T'28/2011 Travis Thompson — BS TEk Inc. 20 ver prtek.com 
