High-Throughput Screening: Discovering New Drugs with Creative Biostructure, Slides of Biology

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high throughput

screening platform

The process of looking for a new drug against a specific target for a

certain disease commonly involves high-throughput screening (HTS),

wherein large libraries of chemicals are tested for their ability to

modulate the biological activity of the target. For instance, if the target

is a novel GPCR, compounds will be screened for their ability to inhibit

or stimulate the receptor; if the target is a protein kinase, the chemicals

will be tested for their ability to inhibit the kinase. Creative

Biostructure provides custom high-throughput screening services, and

our biochemical/cell-based HTS technologies allow us to efficiently

screen hits from a variety of compound libraries.

The high-throughput equipment of Creative Biostructure supports the

screening of corresponding compound libraries by various detection

methods, such as optical, fluorescence, radioactive detection

technology, crystallography, and the multi-functional microplate

detection system.

Our HTS compound libraries including but not limited to:

Natural product libraries

Full-scale hit screening libraries

Known bioactive and FDA approved drug libraries

Target-specific libraries ( e.g. GPCR, kinase, ion channel, protease)

Research area-specific libraries ( e.g. epigenetics, autophagy)

Disease-specific libraries ( e.g. cancer, virus infection)

Advantages of our High-throughput Screening services:

• We can perform a wide range of HTS approaches and multiple compound

library screening.

• We have strict quality control (QC) criteria to control the effectiveness of

the HTS process.

• Our team has extensive experience in running automation platforms and

large-scale assays.

• We can develop, optimize, and validate HTS approaches according to

specific targets or other research requirements.

• Our achievements in the development and automation of high-throughput

crystallography methods allow us to efficiently screen many small molecules

for their ability to bind to targets, thereby accelerating the process of finding

innovative drug candidates.

Excerpt from:

https://drug-discovery.creative-biostructure.com/high-

throughput-screening-hts-p