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17.4 AysKocyien defend tre ‘ood Gneneroh._shruch J Sunckonal characteristics Jusiocgien= AK Rs WBCs_, are the only formed clomenk Alu ore aptualh cells saith rucled ,amh organelle. a Su Hho 4 Yo of tot tood valine. They_one_curdiol 4 our defense agaist oliremen . Huey form_o_maviteoony Haak defend. oppinct boc /Vinuser / parasilen wane Lowel tumor cella iV ar > Tay gt "romuert Harawtyn the. circulatory Sys to Heir dargek region. where . mau 2 TEARONATA How Can WBC leave Ye ood stream? " eh oy endotaeliol cella Had form du. Capi_wwalla od sites ot inPommacion . Jeukorytosis. chen te wWBCs count ix over th.ooo cells /P\ ike a normal__rapowe to inkection- Aeuory to | Catanalocgiea Neutrophils Never mesa ovoun Aacanulo eytea _Conteiws gronudes Lymphocytes Lek include: neutrophils. Meno cy}es Monkeys lympho cates eninoplils Eosinopiis Bak Moun cytes Soomophi Borogit —_ Bunanor Aroxt albun - > Sghoricah in_Shape- tuachionally #8 Cachotier > \ploed nutles (rounded nuclear = ‘Their nuclec ove masses connectel tay inner Spherical or \aidney > Their_mem_hound_cyisplonmtic Granules Stains its wrigh’s Stain N i Ov inv f ‘i cue ire ip ivy wawuane LEAPOMLeA. Production and ite span ot oukocslen: (_ Leudopesienis ) paracrine is shinadatcel_ton chun menengers. > Ye act eta oes 5 Thug'tt._Glycopraleing thot Rall into tian Jesmelien od hemodopoictic. Jactors ee wierlewlains colony-Stimwlating factors _(csfs) they're nuntbereol (IL-2, TL-5) Theyte named for luskocr}e. population aay Stimulole _Jor_ex: Granulacytea - CSE _( G-CSf) which SHimulodes Hu production of _granulbcytta- & Hamubogoiekic ductors + fy ave relensect by Sugpocting colle ved lone mart ak mature WRCs_. in_tabicl, Hee prompt tne WDCs_pretarsors 40 divid aul mature amd doo enante Ae protective ce. ct madre _lenkotses- Homenttedic in balance : Hemadeyeiehc armanes CEPO» ouch nam SEs) are wel clinically Thy stinwdabe the tone marrow of Canter pubes who are _veceivin Chemoterapy “voll Suppreasea He lone morcac" ah cf these wlio howe veteived slow seble dronsplant 5. They “re aloo wed 6 beet op Ne profech've reponicn of MOS paAienh.. => produce _ymghncylen from stwyoloich Stam Cella which giver vise to all ofc dumed_dlumenh. In myeloblart—> accumulation 3% \yoromes —> becming Promnyelocyits—> ditlrent qinules of cath gramulbegte 4ype_opgear im _oMYelnOye > “hem clivision Hey. > The nuclei _becomen ) shaped. _produsing fu Band celle — & Before granulacytea Jeove Ye marrow reir vurcles Constricts Starting Hoe procens a Muclear segmentation Ae bone morro Storer mokure Jranulocyis al cowbaina granulocyen \oX mote than Me \Nood. - 4 Normal xoklo st Granuhocyles » erpthroesite Produced in 3:1 + Which ceMetts — granulorg ts’ shorter Jife syan- C0-29-% dows) , ancl mort die Aghting mlcroorganivmd. Jineogen 8 Hae -hoo tapes ot agronulocylea :- = Mowocyter —Tand B ymfhoryheo + derived rom Myelaih stom cella. derived. from dyma nid stun cellar. and glare or common grecustor ite T Nyman ches precurtors eave Mne \one wanerors-> Newtrogh:\s Hratt not sharee! wit Yur rowel fo Hymna Cy Ze’ \ 5 ssi) = AMerentinttion oc. fromlety lea. Coks eave Me B_ lymphocuten qrecursors > vsmain ak modure Mono dau > Rromonacyls—> Mob crita.. rate eon morro - dives —sererel Mona — Jive, for daw hes - decader. deutoperios dover ovo. ws count, sade dru (glcocorknidh mn onkanese agent) Jeuremion . it refers too. gxp_ oh cancerown conditions aes somcpndectin * ct _obnormal Wis. revo vesptiliced oud itente ouk a conte soggy perma ced None marrow Sanction. > Thy 're_nomed.__actordine, Yo _Ye_roke oA oleic Hoy gregrers oud luge ch _tel_invswved w Conte Lednemias Slowly advancing cuz i+ invaWwes proliterntion st ater cell stages Lo wd Lymphacitic Lunkenias \avolven lynpluntyies.. . . 4 Chronic. Jeubenir—» feck elder gph J MEY «Sn Be TIN «ong Mn Te baw most common _cuz ot dead are isteach \amoscare md. elds talecloon.. 3 Symptoms fener Mei lois. ancl pone mn Treedmemk :- - \rracktotion antitenremd Temiss ion dashing trom mons -$ e in { owas ble aueclo\ie. Infections _Mononucleosit = — + Mesh is ttyfdly combegioun viral diseare ently in Young _cachubta. s 2 - N The dheone, nave a balhmark ob tacomive mno- ok Aymginen, Many ri Hane lymphoosler ove lara 2 ck alepicah —» nd thoy Lslere Hough 4o we _mondcylen valaich ¢ % mnaning kis d sSymplomar tired, ochy, Chronic Sere tnrook . anh lorgrade wer. Sone! L vwitle_vea! s wittia Ue weet Table 17.2 Summary of Formed Elements of the Blood Erythrocytes (red Biconcave, anucleate 4-6 million D: about 15/days) Transport oxygen blood cells, RBCs) disc; salmon-colored; LS: 100-120 days _ and carbon dioxide diameter 7-8 um Leukocytes (white Spherical, nucleated 4800-10,800 blood cells, WBCs) cells Granulocytes * Neutrophil Multilobed nucleus; 3000-7000 D: about 14 days) Phagocytize bacteria inconspicuous Ls: 6 hoursto a few, cytoplasmic granules; days: diameter 10-12 ym * Eosinophil BilobedinUCeUs red — 100-400 D: about (4/days Kill parasitic worms; cytoplasmic granules; Ls: about 5 days complex role in diameter 10-14 um allergy and asthma * Basophil Bilobed nucleus; 20-50 D:27idays Release histamine large purplish-black LS:afewhourstoa and other mediators cytoplasmic granules; few days. of inflammatior diameter 10-14 ym contain heparin, an anticoagulant Agranulocytes + Lymphocyte Spherical or 1500-3000 D: days to Weeks Mount immune indented nucleus; Ls: to years: response by direct pale blue cytoplasm; cell attack or via diameter 5-17 ym antibodies * Monocyte U-orkidney-shaped 100-700 D: 2a3days) Phagocytosis; nucleus; gray-blue LS:imonths) develop into cytoplasm; diameter macrophages in the 14-24 ym tissues Platelets 4 Discoid cytoplasmic 150,000-400,000 D: 4-5 days Seal small tears é ° fragments LS: 5-10 days in blood vessels; q containing granules; instrumental in o,0 » stain deep purple; blood clotting 4 A diameter 2-4 ym % & 
