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143 Ste ish - Bicontave discs “ Flattened disc with depremed. Centers. Madre erytimcsten _Ihewe P.M, ow _onurleat onl have na organcllen “tly _c1re._bages a hemoslobin CHb) "The ero Hink's a goa tran porter mointein ti. Wiconcave Shope [hs deeraka alley erythneyls 4 ch Change Shope nul resume Ie picka on, in Capillaries in tae danga A7_releme +t 404s iue0. Ue aldo tram 90% dt Coa from tixiues to dh Songs g Structaral characteristics 4 enytnrocyler Hust Conbvilowten to Muir gan tram dunctions: ay hae “SA 40 rato due to Huis small size oul shope » auch Me cise tage ceduien He area from He cylegloam do tke surface making it ideok fer gan ¢achomge. b 13-195, in_mahes 1a-thg in demaden “ . en “n + Each. heme rp bears _an_iron ion Ce") in Mae comter. —# Hemogistin > Can _‘ind 4 6, molecular - 4 Fach PRK Wane GO MILLION _hamegistin So 20th Can _ ScoaR__vy SoA Billion 63 _ mleculen. Howerer we hove fee henceslalin ‘iw Mar. ‘o\ood Munk -maclven Sie more _wis.cota stil would craw water from _Hiaswes into Mu. \olooda ream tet osmests. origgtn Loading occurs tm Hee Juana au) gph trawigorled 40 oMear Ritue cella. A. Ory deficient Solood goer te Hu Dunya The_ivon is partially oxidizedby 0: 2.074 difiunea rom ste oir Sack to Hae Telted te exytarncytes scohere We Winds iver - Dus cntalnernnalolein ann ONgumeh Tn \oody Siatines Mae procem is vv. Oa de ennoslo\sin hemoglobin. m"\ ov) Ht becomen dor red. oo ox _reduceel Carbaminonemodo\in: 20% ch (Or tramporteh in Soloed \sinds remadiidsin, “Ut \etndo a.o. vodhur Hann neme gre” Ws forms, ( Arbaminohemodorsin occurs when Wo is in Hue veduted stete CO, Leasing occurs tn tissues ———> front Aung. Production fs bey Hnrocten = AKR = hemalopoieris Orourt in Mae ved teane marrote tla compertsh Layaha, A soth nokwnrk ot vekicular Connective on nue. . . oes ida: serfet This_nektaor hh _olao contains immahwze lolood cella» macro phages, fab cella. cms rehicedur cell - a The Production ot each, type a} blood. cells varies im reaponae te Uso? \m_reagonie to - clronging —\oody needa ~requlabery ductors Regulakion ond. RKequiremenks hr Exptnopoienis £TWe_no. dk _circulaking erpurocrten is ohh 27 eck aloahante Seekwoten RRL production (olerkucHon Too_duar_enytororyben = Hypeaig _Coa_ deprivation) Too mans enythrovstes = modes tctood sea Vixtows, How Cau we udure tat fre no- im rolood skeuys vari Vue Inomenttebic cange’] nee cella ore produced ok a rapid rote ct _more Mann 2M ger sec in _\wealiiey 99) Win _ proces _is_ Controlled ‘ey \normonta onl _clepensls om _emovsl _spply 6 irons c-0 anh Some BB Vikeminy. Hormonal Controls: Englurnpoiedin (EPO) > is a glcprokin Wwormone . Haak stimulates Mu formation ot ecytinmsytes Lig dn needed in smal amount In “osdstream 19 sua NEC grodacton ata bodol roe. Minoan gles co _maior role ‘mn ERO seduction . ov iver odno spedisea come. _vowen _Wwidiney _Cedh s_Noe Cone Wag atic. 703 Sensitive @nz are _wnalate Se comes ovd Hater sarmah funtion deyrading on inva. Cellular modecuke called —_hyyaoricr ~ tnducile doctor (HIS) # AVE actumulodon = arceleroken He surtaeris amd releone ot 620 Corutintsgiekin © sexutts Geom > LL no. cL ABCs due So hemorrhage or excemive AW Aeaerciion. a wns hRiclenk Nemogihia ger BRC in tron dehkiclenty® > Aw Oatladi\iy ok On“ in Taliituden ox Auring,_gneamoni* bohak hogpenes um we hone WM Or/ erythrocy er Jovela? The reverse iS fue, Ye \plocd.strenm deprerstn arytnropol atin production . note: th not He no. A ery tok __controls Yae_vode. ot -eesthropoienis Wa controled loosed on ther obiity tro. Arann 03, 40 meet tisSue clemanels. a Erytropotetin stimulokes ved mara cella Hut ore heady committal to \eecome tmgtratg hs > _Cazing Hun 40 molure utter. Aypozia DOESN'T activede Hae lone marrors dmecty \_stvnuhohes Heo Vicinens at7 udlnich provide Aw. \rormonah stimulus 7 To ockiuabe Hu. ‘oome marrovs. homeoSlatic _\minakante « Some aWekxs aowre ERO velomioinant , “Pro WKS TOKerS omel movtodkhon ‘Yunners’ Ye mereade — draminn “resistence + adh gecrormunce. “Wn cons come dendly - By om gecing EPO, Hay Awe xe, normal nemodecrit from 4a% — 69% , + He obey diction HruAocctars baring Hie race, He brood comcemreoke mare =7 ecomins more Nnick , SHeks wich _Camney _cloing, shroKe , or Vee + Fuilure. “ey Maher Wome on Seier REC count wd "ems deba Hate ence ult wien nc ige sieht seonordize "aod cdd gop ‘dine * cl carey: > trons Me for enatare ester SynYauss. Like owal\odale. From. ‘ek. aad. imextinel cell cowts Wu prettie alosorgtion into ' : ° \ | wn Temoranind * i Spleen are smoll omount in ‘one martons. = Sete won Che, Fe") ig domte => Mua thr stored snide cella as prolen icon tomelen ferrin on nem oSid.erin = An loloodk ivan ss ATana —_Lantely round 40 a enn gto Cobled, transferrin . aed women Lose > \mg due, to menshocion its higher Vaem men. Mem lode > 0:T.mg Fode oncl Desdruckion ob Erytnroester:- ts re th techy nuclews # spleen = RECS graweyard : One of § loloin in_hemee glabin.. Sitkling veduter malaria. parasiter cleility 40 Survive onl dhane —macroploges ability to. destroy iwheled PRC ack Muir paroaile. Treakment :- to prorak RRs from sickling # Fefal hemoglobin (HE) daeart sicke even iP its destined 40. Hydlrorguren.: ‘Drag _useok +6 treat Chronic leukemic, » which switthen lwk tre Bal Hb June on He teoluten the pain. sel Me Severity “Complications ley 0% . Iw Children whe are severly offered, 2 Wwe do tor Hum bone mamtow siem Cella tramplawts lich Sher Complele cure , bot _its risky. a. Poy (J sy Hoenn. ‘ alonormat eacters ot arylacotp ier uk MY blood viscosity . cumtuy it to Hows slupyishly . = Polycythumicr Nera s= Cuzer: a bone mayrow cancer, characterized by clizzinens awk very 4M ABCs Wemalo uit mung be 0% aud. blood volume vnwy double ceaults : Vanwlar Sy to loecome engorgeal voitts blood aud. suvarely impairs cirtuloion. treckment: -theropentic phlebotomy» procedure st vemaing Some loleod.. — Secondary polycuttumias « Cz: -de Or. = EPO productionis it appecars in tueliv Hing in_high alfitclen its normal ply_rexpoure 40 Jae xeduteel atmospheric _preaure nel, Aowet Os Cowtenk in dubs? auean, - Blood. doping := th orkfeetally induceel polycythemia if pratticeel by Some adkletea _Comyebing in_aerobbic_evendt Hovowsvo)) Some & iw athlettn RECs are droson dK oud shored’, “Then Ba leds relates tu Lyst hood toy erytaro poletin meth. “tun Huy reinfuue Hae Stored ood few Noptore te _ativletic. ewe a temporary _ polycatlaemia result. > 40 inc endarante ouch ipeecl due to AS Wemoteorit. Actor trom He ris of stoke al \mtk fellure due to AY \nemabeert oul ANE rood Soest it works. Howener te lbanned from compebitve spar wre ty Cownichered _unettaicol - 
